Laryngopharyngeal Reflux (LPR) Correlation to Middle Ear Disorders

Mohammad Dwijo Murdiyo, Melody Audria Kurniadi

Abstract


Laryngopharyngeal reflux (LPR) is a condition where the reflux of gastric contents reaches the laryngopharynx. Several studies have learned that LPR can cause disturbances in the organs around the larynx pharynx and one of the organs affected is the ear. LPR complications in the middle ear can reduce the quality of life of sufferers. Appropriate diagnostic methods are needed to provide appropriate therapy for this complication. To analyze the relationship between Laryngopharyngeal Reflux (LPR) and middle ear disorders. This study was an analytic observational study using a purposive sampling approach where the assessment of correlation tests between variables was tested with SPSS. Results: Demographic data of LPR patients are dominated by female gender (56%) with an age range of 19 - 59 years (80%). The maximum Reflux Symptom Index (RSI) score in LPR patients is 33 and the maximum Reflux Finding Score (RFS) score in LPR patients is 25. An abnormal Tympanogram Width (Tw) picture was found in 64% of LPR patients. Abnormal compliance picture was found in 36% of patients with LPR and abnormal middle ear pressure picture occurred in 12% of patients with LPR. Abnormal middle ear disorders were found in 88% of patients with LPR. Correlation test assessment between RSI score and Tw parameter and correlation between RFS score and middle ear pressure. There was a positive correlation between LPR and middle ear disorders. There is a positive correlation between LPR and middle ear disorders.

Keywords


Middle Ear Disorders; Laryngoesophageal Reflux; LPR; Tympanogram Width

Full Text:

PDF

References


Brar, S., Watters, C., Watson, N., Birchall, M., & Karagama, Y. (2022). Ear, nose and throat (ENT) manifestations and complications of reflux. Frontline Gastroenterology, 13(e1), e57–e64. doi: 10.1136/flgastro-2022-102184

Brown, J., & Shermetaro, C. (2025). Laryngopharyngeal Reflux.

Flood, L. M. (2016). ESSENTIALS OF AUDIOLOGY, 4th edn. S A Gelfand . Thieme, 2016. ISBN 978 1 60406 861 0 pp 536 Price £65.50 €79.99. The Journal of Laryngology & Otology, 130(8), 787–787. doi: 10.1017/S0022215116008094

Han, H., & Lv, Q. (2018). Characteristics of laryngopharyngeal reflux in patients with chronic otitis media. American Journal of Otolaryngology, 39(5), 493–496. doi: 10.1016/j.amjoto.2018.05.010

Hanrahan, J. E., Calista, N., Ardiantara, S., Restuti, R. D., Irawati, N., & Rachmawati, E. Z. K. (2024). Effectiveness of Proton Pump Inhibitor Therapy in Children with Chronic Otitis Media: an Evidence-Based Case Report. Journal Of The Indonesian Medical Association, 73(6), 292–298. doi: 10.47830/jinma-vol.73.6-2024-870

Huang, F., Liao, Q., Gan, X., & Wen, W. (2022). Correlation Between Refractory Laryngopharyngeal Reflux Disease and Symptoms of Anxiety and Depression. Neuropsychiatric Disease and Treatment, Volume 18, 925–932. doi: 10.2147/NDT.S349933

Karyanta, M., Satrowiyoto, S., & Wulandari, D. P. (2019). Prevalence Ratio of Otitis Media with Effusion in Laryngopharyngeal Reflux. International Journal of Otolaryngology, 2019, 1–3. doi: 10.1155/2019/7460891

Lechien, J. R. (2022). Treating and Managing Laryngopharyngeal Reflux Disease in the Over 65s: Evidence to Date. Clinical Interventions in Aging, Volume 17, 1625–1633. doi: 10.2147/CIA.S371992

Lechien, J. R., Vaezi, M. F., Chan, W. W., Allen, J. E., Karkos, P. D., Saussez, S., Altman, K. W., Amin, M. R., Ayad, T., Barillari, M. R., Belafsky, P. C., Blumin, J. H., Johnston, N., Bobin, F., Broadhurst, M., Ceccon, F. P., Calvo?Henriquez, C., Eun, Y., Chiesa?Estomba, C. M., … Carroll, T. L. (2024). The Dubai Definition and Diagnostic Criteria of Laryngopharyngeal Reflux: The IFOS Consensus. The Laryngoscope, 134(4), 1614–1624. doi: 10.1002/lary.31134

Pang, K., Di, Y., Li, G., Li, J., Li, X., & Sun, L. (2020). Can Reflux Symptom Index and Reflux Finding Score Be Used to Guide the Treatment of Secretory Otitis Media in Adults? ORL, 82(3), 130–138. doi: 10.1159/000505929

Rosen, C. (2023). Bailey’s Head and Neck Surgery : Otolaryngology: Vol. II (F. Shahidi, Ed.; 6th ed.). Philadelphia: Wolters Kluwer. doi: 10.1002/047167849X

Saleh, S., Trujillo, S., Ghoneim, S., Thomas, C., & Fass, R. (2023). Effect of Hormonal Replacement Therapy on Gastroesophageal Reflux Disease and its Complications in Postmenopausal Women. Clinical Gastroenterology and Hepatology, 21(2), 549-551.e3. doi: 10.1016/j.cgh.2022.01.058

Widiantari, I. A. A., & Sucipta, I. W. (2019). Karakteristik penderita laryngopharyngeal reflux yang didiagnosis berdasarkan reflux symptom index dan reflux finding score di Poliklinik THT-KL RSUP Sanglah Tahun 2015-2017. Medicina, 50(3). doi: 10.15562/medicina.v50i3.678

Xiao, S., Li, J., Zheng, H., Yan, Y., Li, X., Zhang, L., Lv, Q., Zhang, J., Zeng, L., Gao, X., Chen, X., Yang, H., Zhao, C., Zhang, J., Lu, H., Luo, X., Wang, G., Yi, H., Ye, J., … Ren, J. (2020). An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China. European Archives of Oto-Rhino-Laryngology, 277(10), 2829–2838. doi: 10.1007/s00405-020-06045-0

Zakaria, M., Romli, M., Mohamad, W. W., Awang, M., & Wahab, N. A. (2020). The diagnostic value of tympanometric width in identifying middle ear disorders. Indian Journal of Otology, 26(3), 186. doi: 10.4103/indianjotol.INDIANJOTOL_120_19




DOI: https://doi.org/10.14421/biomedich.2025.141.315-321

Refbacks



Bookmark and Share


Copyright (c) 2025 Mohammad Dwijo Murdiyo, Melody Audria Kurniadi



Biology, Medicine, & Natural Product Chemistry
ISSN 2089-6514 (paper) - ISSN 2540-9328 (online)
Published by Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity.

CC BY NC
This work is licensed under a CC BY-NC