Antihypercholesterolemic Activity of Tahongai Leaf infusion (Kleinsovia hospita L.) In Mice (Mus musculus L.)

Sister Sianturi, Clara Ritawany Sinaga, Nurillahi Febria Leswana, Maria Elvina Tresia Butar-Butar

Abstract


Tahongai (Kleinhovia hospita L.) is an indigenous plant of East Kalimantan known for its health benefits, including antibacterial, anti-inflammatory, antioxidant, anticancer, and antidiabetic properties. This study evaluates the antihypercholesterolemic activity of Tahongai leaf infusion in hypercholesterolemic mice (Mus musculus L.), induced by egg yolk. The test groups included a positive control (simvastatin), a negative control (distilled water), and three treatment groups with Tahongai leaf infusion at concentrations of 15%, 30%, and 60%. The results indicated that the highest reduction in cholesterol levels was observed in the P1 group (15% infusion) with an average decrease of 30.84%, followed by P2 (30% infusion) at 24.79%, and P3 (60% infusion) at 9.31%. The positive control group showed an average reduction of 8.64%. Statistical analysis using One-Way ANOVA revealed a significant difference (p<0.05) in cholesterol level reduction among the treatment groups.

Keywords


Anticholesterol; Tahongai Leaf; Kleinshovia hospita L; Hipercholesterolemia; Mice

Full Text:

PDF

References


Adfa, M. (2007). Isolasi Senyawa Flavonoid Aktif Berkhasiat Sitotoksik Dari Daun Kemuning (Murraya panicullata L. Jack). Jurnal Gradien. 3(2): 262–266.

Aji, N., Rubiyanti, R., Kementerian, P. K., Tasikmalaya, K., & 35, C. N. (2021). Potensi Infusa Daun Tradescantia spathaceae Sebagai Tabir Surya pada Sediaan Gel Menggunakan Metode Spektrofotometri UV-Vis. Jurnal Ilmu Kefarmasian Indonesia, 20(1), 6–13.

Artha, C., A.Mustika dan S.W. Sulistyawati. 2017. Pengauh Ekstrak Daun Singalawang Terhadap Kadar LDL Tikus Putih Jantan Hiperkolesterolemia. E-Jurnal Kedokteran Indonesia Vol.5 No.2 pp 105-109

Arung, E. T., Kusuma, I. W., Purwatiningsih, S., Roh, S. S., Yang, C. H., Jeon, S., Kim, Y. U., Sukaton, E., Susilo, J., Astuti, Y., Wicaksono, B. D., Sandra, F., Shimizu, K., & Kondo, R. (2009). Antioxidant Activity and Cytotoxicity of the Traditional Indonesian Medicine Tahongai (Kleinhovia hospita L.) Extract. Journal of Acupuncture and Meridian Studies, 2(4), 306–308. https://doi.org/10.1016/S2005-2901(09)60073-X

Aviani, R.R., Sumadji, A.R., Kirana, B.C. 2022. Uji Efek Antikolesterol Daun Kemuning (Murraya paniculata Jacq.) Terhadap Mencit Jantan (Mus musculus L.). Biospektrum Jurnal Biologi. Vol.1 No.1 pp 84-90

Bonsdorff-Nikander, A.V. 2005. Studies on a Cholesterol Lowering Microcrystalline Phytosterol Suspension Oil [Disertasi]. Faculty of Pharmacy, University of Helsinki, Finlandia.

Chamila, O. (2017). Standardisasi dan Uji Antiinflamsi Ekstrak Etanol Daun tahongai (Kleinhovia hospita L.) Terhadap Tikus (Rattus norvegicus) Jantan Galur Wistar. https://repository.unsri.ac.id/19825/(04/09/2021:22:51

Clara, T. G., & Alfarabi, M. (2019). Toksisitas Ekstrak Daun dan Kulit Batang Tahongai (Kleinhovia hospita L.) Menggunakan Metode Brine Shrimp Lethality Test (BSLT)

Djabir, Y. Y., Arsyad, A., Murdifin, M., Tayeb, R., Amir, M. N., Kamaruddin, F. A. F., & Najib, N. H. (2020). Kleinhovia hospita extract alleviates experimental hepatic and renal toxicities induced by a combination of antituberculosis drugs. Journal of HerbMed Pharmacology 10(1), 102–108. https://doi.org/10.34172/jhp.2021.10.

Dwianita C., Tandi, J., Dermiati T. 2017. Pengaruh Pemberian Ekstrak Etanol Daun Talas (Colocasia esculenta L.) Terhadap Penurunan Kadar Kolesterol Total Darah Tikus Putih Jantan (Rattus norvegicus) Yang Diinduksi Pakan Tinggi Lemak dan Streptozotocin. Jurnal Farmasi. Vol 14 No.2

Jones, P.J., M. Raeini-Sarjaz, F.Y. Ntanios, C.A. Vanstone, J.Y. Feng, dan W.E. Parsons. 2000. Modulation of Plasma Lipid Levels and Cholesterol Kinetics by Phytosterol versus Phytostanol Esters. J. Lipid Res. 41:697-705

Karimuddin, F. A. (2018). Pengaruh Pemberian Ekstrak Etanol Daun Paliasa (Kleinhovia hospita L) Terhadap Gambaran Histopatologi Hati Tikus Yang Diinduksi Obat Antituberkolosis Kombinasi Dosis tetap (OAT-KDT). http://digilib.unhas.ac.id/ uploaded_files/temporary/DigitalCollection.

Kou, S., Han, B., Wang, Y., Huang, T., He, K., et al. 2016. Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters. Life Sci. 2016.15;151:50-6

Menkes RI. 2018. Hasil Utama Riskesdas 2018. Kementerian Kesehatan Republik Indonesia. Jakarta Selatan

Mufida, M., Rahman, N., & Supriadi, S.2018. Efek Ekstrak Daun Alpukat (Persea Americana, Mill.) Dalam Menurunkan Kadar Kolesterol Darah Pada Mencit (Mus musculus L.) Jurnal Akademika Kimia Vol. 7 No.1

Muqowwiyah, Z.L.& Dewi, R.K. 2020. Potensi Ekstrak Daun Alpukat Sebagai Anti Kolesterol. Jurnal Tadris IPA Indonesia. Vol.1 No.3, pp 403-412

Murray, R.K. 2009. Biokimia Harper. Edisi 27. EGC: Jakarta

Nugraha, T. 2011. Pengaruh Ekstrak Daun Salam (Syzigium polyanthum) Terhadap Penurunan Kadar LDL Kolesterol Darah Tikus Putih (Rattus norvegicus). Skripsi. Universitas Sebelas Maret: Surakarta.

Rusli, R., Hafid, M., & Badjadji, N. N. (2018). Uji Efektivitas Antibakteri Kombinasi Ekstrak Daun Paliasa (Kleinhovia hospita L) Varietas Bunga Putih Dan Bunga Ungu Terhadap Pertumbuhan Staphylococcus aureus dan Escherichia coli. Jurnal Media Farmasi, 14(1), 59. https://doi.org/10.32382/mf.v14i1.92.

Saputra, S.H. 2021. Fitokimia, Aneka Produk dan Manfaat dari Ekstrak Daun Tahongai (Kleinshovia hospita L.). Jurnal Riset Teknologi Industri. Vol. 15 No.2

Sari, T. P., Rijai, L., & Gama, S. I. 2016. Potensi Antiinflamasi Ekstrak Daun Tahongai (Kleinhovia hospita L). In Prosiding Seminar Nasional Kefarmasian Ke-4 (pp. 364–371). Fakultas Farmasi Universitas Mulawarman. https://doi.org/10.25026/ mpc.v4i1.206

Suyatna, F.D. 2007. Hipolipidemik in: Gunawan S.G. Setiabudy R, Nafrialdi, Elysabeth. Farmakologi dan Terapi. Edisi 5. Departemen Farmakologi dan Terapeutik FK UI. Jakarta. Pp 373-388

Saragih, B. 2011. Kolesterol dan Usaha-Usaha Penurunannya. Penerbit Bimotry. Yogyakarta

Satrana, D.K. 2017. Uji Efek Analgesik Ekstrak Etanol 70% DaunTegining-Ganang (Cassia planisiliqua Burn.f) Pada Mencit Jantan (Mus musculus L.) Dengan Metode Writhing Reflex. Skripsi. Program Studi Farmasi Fakultas Farmasi ISTN, Depok, Jawa Barat.

Siregar, A.J & D.Elysa P.M.2021. Uji Aktivitas Antikolesterol Ekstrak Etanol Daun Tekelan (Chromolaena odorata L.) Pada Tikus Jantan Putih (Rattus norvegicus) Jurnal Farmasi Sains dan Kesehatan Vol.1 No.1

Suhendra, A.T.& Wuisan, J. 2016. Uji Efek Ekstrak Biji Alpukat (Persea americana Mill.) Terhadap Kadar Kolesterol Total Pada Tikus Wistar (Rattus norvegicus). Jurnal E-Biomedik, Vol 4 No,1, pp 1-6

Tamantuan, D.R, Arman & Masriadi. 2019. Efektivitas Pemberian Air Kelapa Muda dan Rebusan Daun Alpukat Terhadap Penurunan Tekanan Darah Pada Penderita Hipertensi Stadium I di Desa Sipatuo dan Benteng di Kecamatan Patampanua Kabupaten Pinrang. Jurnal Mitrasehat Vol 9 No.1, pp 15-28

Tan, T.H. dan Rahardja. 2010. Obat-Obat Sederhana Untuk Gangguan Sehari-Hari. PT Alex Media Komputindo. Kelompok Gramedia: Jakarta

Yunita, T., Putri Kusuma, A. W., Novita, S. E., & Sulistijono. 2019. Effect of Addition Tahongai Leaf Extract (Kleinhovia hospita Linn.) As Organic Inhibitor on 1040 AISI Steel. IOP Conference Series: Materials Science and Engineering, 547(1). https://doi.org/10.1088/1757-899X/547/1/012006




DOI: https://doi.org/10.14421/biomedich.2025.141.233-238

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2025 Sister Sianturi, Clara Ritawany Sinaga, Nurillahi Febria Leswana, Maria Elvina Tresia Butar-Butar



Biology, Medicine, & Natural Product Chemistry
ISSN 2089-6514 (paper) - ISSN 2540-9328 (online)
Published by Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity.

CC BY NC
This work is licensed under a CC BY-NC