The Relationship Between Total IgE, Symptom Duration, VAS Scores, and Danyoung Classification in Allergic Rhinitis

Ayunita Tri Wirattami, Tanti Agustina

Abstract


Allergic Rhinitis (AR) is an inflammatory condition of the nasal mucosa triggered by allergies, with total IgE often used as a biomarker to assess disease severity. Objective: To analyze the relationship between total IgE levels, symptom duration, Visual Analog Scale (VAS) scores, and Danyoung Classification in AR patients. Methods: A cross-sectional observational analytical study was conducted on 73 patients at the Allergy-Immunology Clinic of Dr. Saiful Anwar General Hospital. Total IgE levels were measured using the ELISA method, while VAS and nasal mucosa classification were assessed through anamnesis and nasoendoscopy. Results: The study showed68.5% of patients had IgE levels above 100 IU/ml, with an average of 982.97 IU/ml. Although higher IgE levels were often found in AR patients, there was no statistically significant correlation between IgE levels and Danyoung classification (significance value 0.924). The correlation test showed a coefficient of -0.11, indicating a negative correlation, but it was not statistically significant. Conclusion: The nasal mucosa condition in patients with high IgE levels does not always reflect severe inflammation. In addition to IgE levels, external factors such as exposure to pollutants and cigarette smoke also play a role in the condition of the nasal mucosa. Therefore, while high IgE levels often indicate allergic reactions, this study found no significant relationship between IgE levels and AR severity.

Keywords


Allergic rhinitis; Danyoung classification; total IgE; symptom duration; VAS score

Full Text:

PDF

References


Bonds, R. S., & Midoro-Horiuti, T. (2013). Estrogen effects in allergy and asthma. Current Opinion in Allergy & Clinical Immunology, 13(1), 92–99. https://doi.org/10.1097/ACI.0b013e32835a6dd6

Bousquet, J., Anto, J. M., Bachert, C., Baiardini, I., Bosnic-Anticevich, S., Walter Canonica, G., Melén, E., Palomares, O., Scadding, G. K., Togias, A., & Toppila-Salmi, S. (2020). Allergic rhinitis. Nature Reviews Disease Primers, 6(1), 95. https://doi.org/10.1038/s41572-020-00227-0

Bousquet, J., Anto, J. M., Wickman, M., Keil, T., Valenta, R., Haahtela, T., Lodrup Carlsen, K., van Hage, M., Akdis, C., Bachert, C., Akdis, M., Auffray, C., Annesi?Maesano, I., Bindslev?Jensen, C., Cambon?Thomsen, A., Carlsen, K. H., Chatzi, L., Forastiere, F., Garcia?Aymerich, J., … von Hertzen, L. (2015). Are allergic multimorbidities and IgE polysensitization associated with the persistence or re?occurrence of foetal type 2 signalling? Allergy, 70(9), 1062–1078. https://doi.org/10.1111/all.12637

Chang, S. (2015). Newly Allergic rhinitis classification by Innovative Endoscopic Diagnostic Method-Danyoung Classification. In HEAD MIRROR JOURNAL (Vol. 1). https://www.researchgate.net/publication/315643658

Chang, S. (2018). Allergic Rhinitis and DANYOUNG Classification Update-2 by Correlation Analysis with Serum Specific IgE Test.

de Paula Couto, T. A. P., Falsarella, N., de Cássia Brandão de Mattos, C., & de Mattos, L. C. (2014). Total IgE plasma levels vary according to gender and age in Brazilian patients with allergic rhinitis. Clinics, 69(11), 740–744. https://doi.org/10.6061/clinics/2014(11)06

Doulaptsi, M., Prokopakis, E., Seys, S., Pugin, B., Steelant, B., & Hellings, P. (2018). Visual analogue scale for sino-nasal symptoms severity correlates with sino-nasal outcome test 22: paving the way for a simple outcome tool of CRS burden. Clinical and Translational Allergy, 8(1), 32. https://doi.org/10.1186/s13601-018-0219-6

Hyun, D.-W., Min, H. J., Kim, M.-S., Whon, T. W., Shin, N.-R., Kim, P. S., Kim, H. S., Lee, J. Y., Kang, W., Choi, A. M. K., Yoon, J.-H., & Bae, J.-W. (2018). Dysbiosis of Inferior Turbinate Microbiota Is Associated with High Total IgE Levels in Patients with Allergic Rhinitis. Infection and Immunity, 86(4). https://doi.org/10.1128/IAI.00934-17

Klimek, L., Bergmann, K.-C., Biedermann, T., Bousquet, J., Hellings, P., Jung, K., Merk, H., Olze, H., Schlenter, W., Stock, P., Ring, J., Wagenmann, M., Wehrmann, W., Mösges, R., & Pfaar, O. (2017). Visual analogue scales (VAS): Measuring instruments for the documentation of symptoms and therapy monitoring in cases of allergic rhinitis in everyday health care. Allergo Journal International, 26(1), 16–24. https://doi.org/10.1007/s40629-016-0006-7

Öçal, R., Bayar Muluk, N., & Mullol, J. (2019). Epidemiology of allergic rhinitis. In In All Around the Nose: Basic Science, Diseases and Surgical Management (pp. 297–301). Springer International Publishing.

Sharma, K., Akre, S., Chakole, S., & Wanjari, M. B. (2022). Allergic Rhinitis and Treatment Modalities: A Review of Literature. Cureus. https://doi.org/10.7759/cureus.28501

Small, P., Keith, P. K., & Kim, H. (2018). Allergic rhinitis. Allergy, Asthma & Clinical Immunology, 14(S2), 51. https://doi.org/10.1186/s13223-018-0280-7

Weare-Regales, N., Chiarella, S. E., Cardet, J. C., Prakash, Y. S., & Lockey, R. F. (2022). Hormonal Effects on Asthma, Rhinitis, and Eczema. The Journal of Allergy and Clinical Immunology: In Practice, 10(8), 2066–2073. https://doi.org/10.1016/j.jaip.2022.04.002

Zachreini, I., Suprihati, Lubis, M. N. D. L., & Koesoema, A. (2015). Uji Diagnostik Histopatologi untuk Konka Hipertrofiyang Disebabkan Rinitis Alergi dan Rinitis Non-alergi. CDK-228, 42(5).




DOI: https://doi.org/10.14421/biomedich.2025.142.957-960

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2025 Ayunita Tri Wirattami, Tanti Agustina



Biology, Medicine, & Natural Product Chemistry
ISSN 2089-6514 (paper) - ISSN 2540-9328 (online)
Published by Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity.

CC BY NC
This work is licensed under a CC BY-NC