Link of Nasopharyngeal Carcinoma and Epstein-Barr Virus

Sugiyanto Sugiyanto, Lina Aryati, Fajar Adi Kusumo, Mardiah Suci Hardianti

Abstract


Nasopharyngeal Carcinoma (NPC) is a cancer that occurs in nasopharynx which is associated with Epstein-Barr Virus (EBV). Mutation agents in nasopharyngeal neoplasms occur because of EBV infection. Transformation of B-cells due to EBV causes hormone imbalance in lymphoid cells or nasopharyngeal epithelial tissue. Rates of EBV infection have been shown to be prognostic to NPC. The basic level of EBV DNA can be used for stratification prognosis, with higher titers showing greater disease severity and worse outcomes. With mathematical models, there is a correlation between the increase in Epstein-Barr Virus and the increase in Invasive Carcinoma Cells or increase in Nasopharyngeal Carcinoma Cells.

Keywords


Nasopharyngeal Carcinoma (NPC); Epstein-Barr Virus (EBV); mathematical model; Invasive Carcinoma Cells

Full Text:

PDF

References


Adham, M., Kurniawan, A. N., Muhtadi, A. I., Roezin, A., Hermani, B., Gondhowiardjo, S., ... & Middeldorp, J. M. (2012). Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation. Chinese journal of cancer, 31(4), 185.

Aryati, L., Adi-Kusumo, F., & Hardianti, M. S. (2016). A Cellular Mathematical Model of Nasopharyngeal Carcinoma with Addition Compartment of Virus. Far East Journal of Mathematical Sciences, 100(8), 1289.

Bale Jr, J. F. (1999, December). Human herpesviruses and neurological disorders of childhood. In Seminars in Pediatric Neurology (Vol. 6, No. 4, pp. 278-287). WB Saunders.

Chong, V. F., Fan, Y. F., & Khoo, J. B. (1996). Nasopharyngeal carcinoma with intracranial spread: CT and MR characteristics. Journal of computer assisted tomography, 20(4), 563-569.

Chua, M. L., Wee, J. T., Hui, E. P., & Chan, A. T. (2016). Nasopharyngeal carcinoma. The Lancet, 387(10022), 1012-1024.

Fachiroh, J., Schouten, T., Hariwiyanto, B., Paramita, D. K., Harijadi, A., Haryana, S. M., ... & Middeldorp, J. M. (2004). Molecular diversity of Epstein-Barr virus IgG and IgA antibody responses in nasopharyngeal carcinoma: a comparison of Indonesian, Chinese, and European subjects. The Journal of infectious diseases, 53-62.

Hendrix, R. (2013). Oncogenic herpesviruses: viral mechanisms and modified immune responses involved in oncogenesis (Master's thesis).

Hu, L. F. (1996). Nasopharyngeal carcinoma and epstein-barr virus.

Huynh, G. T. (2010). Mathematical Models of Epstein-Barr Virus Infection and Associated Diseases (Doctoral dissertation, Department of Mathematics, University of Utah).

Kong, Q. L., Hu, L. J., Cao, J. Y., Huang, Y. J., Xu, L. H., Liang, Y., ... & Chen, Q. Y. (2010). Epstein-Barr virus-encoded LMP2A induces an epithelial–mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS pathogens, 6(6), e1000940.

Liebowitz, D. (1994, June). Nasopharyngeal carcinoma: The Epstein-Barr virus association. In Seminars in oncology (Vol. 21, No. 3, pp. 376-381).

Lin, C. T., Lin, C. R., Tan, G. K., Chen, W., Dee, A. N., & Chan, W. Y. (1997). The mechanism of Epstein-Barr virus infection in nasopharyngeal carcinoma cells. The American journal of pathology, 150(5), 1745.

Lin, J. C., Jan, J. S., Hsu, C. Y., Liang, W. M., Jiang, R. S., & Wang, W. Y. (2003). Phase III study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma: positive effect on overall and progression-free survival. Journal of clinical oncology, 21(4), 631-637.

Lo, K. W., To, K. F., & Huang, D. P. (2004). Focus on nasopharyngeal carcinoma. Cancer cell, 5(5), 423-428.

Lu, J. J., Cooper, J. S., & Lee, A. W. (Eds.). (2010). Nasopharyngeal cancer: multidisciplinary management. Springer Science & Business Media.

McDermott, A. L., Dutt, S. N., & Watkinson, J. C. (2001). The aetiology of nasopharyngeal carcinoma. Clinical Otolaryngology & Allied Sciences, 26(2), 82-92.

Mimi, C. Y., & Yuan, J. M. (2002, December). Epidemiology of nasopharyngeal carcinoma. In Seminars in cancer biology (Vol. 12, No. 6, pp. 421-429). Academic Press.

Morrison, J. A., Gulley, M. L., Pathmanathan, R., & Raab-Traub, N. (2004). Differential signaling pathways are activated in the Epstein-Barr virus-associated malignancies nasopharyngeal carcinoma and Hodgkin lymphoma. Cancer research, 64(15), 5251-5260.

Nurhantari, Y., Emoto, N., Rahayu, P., & Matsuo, M. (2003). Nasopharyngeal carcinoma in Indonesia has a low prevalence of the 30-base pair deletion of Epstein-Barr virus latent membrane protein 1. Southeast Asian journal of tropical medicine and public health, 34(1), 98-105.

Old, L. J., Boyse, E. A., Oettgen, H. F., De Harven, E., Geering, G., Williamson, B., & Clifford, P. (1966). Precipitating antibody in human serum to an antigen present in cultured Burkitt's lymphoma cells. Proceedings of the National Academy of Sciences, 56(6), 1699-1704.

Shah, J. P., Patel, S. G., & Singh, B. (2012). Head and neck surgery and oncology. Elsevier Health Sciences.

Sheen, T. S., Ko, J. Y., Chang, Y. L., Chang, Y. S., Huang, Y. T., Chang, Y., ... & Hsu, M. M. (1998). Nasopharyngeal swab and PCR for the screening of nasopharyngeal carcinoma in the endemic area: a good supplement to the serologic screening. Head & Neck: Journal for the Sciences and Specialties of the Head and Neck, 20(8), 732-738.

Stevens, S. J., Verkuijlen, S. A., Hariwiyanto, B., Fachiroh, J., Paramita, D. K., Tan, I. B., ... & Middeldorp, J. M. (2005). Diagnostic value of measuring Epstein-Barr virus (EBV) DNA load and carcinoma-specific viral mRNA in relation to anti-EBV immunoglobulin A (IgA) and IgG antibody levels in blood of nasopharyngeal carcinoma patients from Indonesia. Journal of clinical microbiology, 43(7), 3066-3073.

Wang, H. Y., Sun, B. Y., Zhu, Z. H., Chang, E. T., To, K. F., Hwang, J. S., ... & Lee, M. (2011). Eight-signature classifier for prediction of nasopharyngeal carcinoma survival. Journal of clinical oncology, 29(34), 4516-4525.

Wu, H. C., Lin, Y. J., Lee, J. J., Liu, Y. J., Liang, S. T., Peng, Y., ... & Lin, C. T. (2003). Functional analysis of EBV in nasopharyngeal carcinoma cells. Laboratory investigation, 83(6), 797.

Zheng, H., Li, L. L., Hu, D. S., Deng, X. Y., & Cao, Y. (2007). Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma. Cell Mol Immunol, 4(3), 185-196.

Zeng, M. S., & Zeng, Y. X. (2010). Pathogenesis and etiology of nasopharyngeal carcinoma. In Nasopharyngeal Cancer (pp. 9-25). Springer, Berlin, Heidelberg.




DOI: https://doi.org/10.14421/biomedich.2018.72.51-55

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2018 Sugiyanto Sugiyanto, Lina Aryati, Fajar Adi Kusumo, Mardiah Suci Hardianti



Biology, Medicine, & Natural Product Chemistry
ISSN 2089-6514 (paper) - ISSN 2540-9328 (online)
Published by Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity.

CC BY NC
This work is licensed under a CC BY-NC