Effectiveness Test of Melon Fruit Peel Ethanol Extract Cream (Cucumis melo) on Incision Wound Healing of White Rats (Rattus norvegicus)

Husna Rizki, Harlita Harlita

Abstract


Incision wounds are a type of open wound that requires treatment to prevent infection and accelerate healing. Using natural ingredient-based creams has become a more practical alternative to conventional ointments. Melon rind (Cucumis melo) contains active compounds such as tannins, flavonoids, and phenols that have anti-inflammatory and antimicrobial properties, potentially accelerating wound healing and reducing the risk of infection. This study aims to test the effectiveness of melon rind ethanol extract cream on incision wound healing in white rats (Rattus norvegicus). The study used an experimental method with three treatment groups: control (bacitracin), 15% melon peel extract cream (P1), and 25% melon peel extract cream (P2). Mice were adapted for 7 days before the treatment test. The cream was applied three times a day for 14 days, and wound diameter and body weight were observed every two days. Observation data were analysed using one way ANOVA test version 26.0. The results showed that melon rind extract cream had physical characteristics that met the standards. ANOVA and LSD tests on wound diameter showed significant differences between control and treatment, although there was no significant difference between P1 and P2. Meanwhile, the ANOVA and LSD test results on body weight showed significant differences between groups. Group P2 showed a steady increase in body weight, indicating the safety of the cream.

Keywords


Experiment; Melon Fruit Peel (Cucumis melo); Cream; Incision Wound; White Rat (Rattus Norvegicus)

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References


Adhikari, A., Barakoti, H., & Kumar Dey, B. (2021). Evaluation of Acute Dermal Irritation, Sensitization and Acute Dermal Toxicity of Leather Cream in Laboratory Animals. Indo Global Journal of Pharmaceutical Sciences, 11(03), 01–06. https://doi.org/10.35652/igjps.2021.113001

Akhmadi, C., Utami, W., & Annisaa’, E. (2022). Senyawa Fitokimia dan Aktivitas Farmakologi Family Basellaceae sebagai Obat Luka : A Narrative Review. Generics: Journal of Research in Pharmacy, 2(2), 77–85. https://doi.org/10.14710/genres.v2i2.13798

Alatas, A., & Anindhita, M. A. (2023). Pengaruh Carbopol 940 Sebagai Gelling Agent Terhadap Karakteristik Fisikokimia Sediaan Masker Gel Peel-Off Ekstrak Kulit Buah Melon Oranye (Cucumis melo L.). BENZENA Pharmaceutical Scientific Journal, 1(02), 56–71. https://doi.org/10.31941/benzena.v1i2.2326

Bawotong, R. A., De Queljoe, E., & Mpila, D. A. (2020). Uji Efektivitas Salep Ekstrak Daun Jarak Pagar (Jatropha curcas L.) Terhadap Penyembuhan Luka Sayat Pada Tikus Putih Jantan Galur Wistar (Rattus norvegicus). Pharmacon, 9(2), 284. https://doi.org/10.35799/pha.9.2020.29283

Bihani, T., & Mhaske, N. (2020). Evaluation of in vivo wound healing activity of Plumeria obtusa L. (Champa) spray in rats. Wound Medicine, 28(March 2018), 100176. https://doi.org/10.1016/j.wndm.2019.100176

Buzzini, P., Arapitsas, P., Goretti, M., Branda, E., Turchetti, B., Pinelli, P., Ieri, F., & Romani, A. (2008). Antimicrobial and Antiviral Activity of Hydrolysable Tannins. Mini-Reviews in Medicinal Chemistry, 8(12), 1179–1187. https://doi.org/10.2174/138955708786140990

Fahmeyzan, D., Soraya, S., & Etmy, D. (2018). Uji Normalitas Data Omzet Bulanan Pelaku Ekonomi Mikro Desa Senggigi dengan Menggunakan Skewness dan Kurtosi. Jurnal VARIAN, 2(1), 31–36. https://doi.org/10.30812/varian.v2i1.331

Fajrin, F. N., Kurnadi, R. L. S., Kholifah, E., Shobah, A. N., & Halimatusyadiah, L. (2024). Comparison of the Toxicity of Watermelon Rind Extract (Citrullus lanatus) and Melon Rind Extract Using BSLT Method. Jurnal Ilmiah Sains, 24(April), 99–109. https://doi.org/10.35799/jis.v24i1.49263

Fauziah, F. (2022). Studi Formulasi Dan Uji Stabilitas Fisik Sediaan Salep Dan Krim Ekstrak Etanol Daging Buah Kopi Robusta (Coffea canephora). Jurnal Sains Dan Kesehatan Darussalam, 2(1), 1–9. https://doi.org/10.56690/jskd.v2i1.35

Hariningsih, Y., & Hartono, A. (2022). Formulasi Krim Ekstrak Etanol Kulit Pisang Kepok (Musa Paradisiaca Formatypica) Sebagai Penyembuh Luka Bakar. Pengembangan Ilmu Dan Praktik Kesehatan, 1(2), 48–56. https://doi.org/10.56586/pipk.v1i2.213

Ismail, H. I., Chan, K. W., Mariod, A. A., & Ismail, M. (2010). Phenolic Content And Antioxidant Activity Of Cantaloupe (Cucumis melo) Methanolic Extracts. Food Chemistry, 119(2), 643–647. https://doi.org/10.1016/j.foodchem.2009.07.023

Jami’ah, S. R., Ifaya, M., Pusmarani, J., & Nurhikma, E. (2018). Uji Aktivitas Antioksidan Ekstrak Metanol Kulit Pisang Raja (Musa paradisiaca sapientum) Dengan Metode DPPH (2, 2-difenil-1-pikrilhidrazil). Jurnal Mandala Pharmacon Indonesia, 4(1), 33–38.

Khairani, T. N., Rumanti, R. M., Manao, A., Farmasi, D., Farmasi, F., Helvetia, I. K., Farmasi, M., Farmasi, F., Helvetia, I. K., Noverita, T., Institut, K., Helvetia, K., Kapten, J., & No, S. (2020). Formulasi Sediaan Krim Ekstrak Etanol Kulit Buah Manggis ( Garcinia mangostana L .) Sebagai Obat Luka Bakar Pada Tikus Putih Jantan. Jurnal Dunia Farmasi, 4(2), 53–58.

Lumentut, N., Edi, H. J., & Rumondor, E. M. (2020). Formulasi dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Kulit Buah Pisang Goroho (Musa acuminafe L.) Konsentrasi 12.5% Sebagai Tabir Surya. Jurnal MIPA, 9(2), 42. https://doi.org/10.35799/jmuo.9.2.2020.28248

Mahmudah, B. H., Umboro, R. O., & Apriliany, F. (2021). Uji Efektivitas Ekstrak Daun Ciplukan (Physalis angulata L.)Terhadap Penyembuhan Luka Sayat Pada Kelinci Jantan (Oryctolagus cuniculus) Galur Wistar. Cendekia Journal of Pharmacy, 5(2), 196–205.

Oeleu, K. Y. (2022). Uji Aktivitas Gel Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius roxb) Terhadap Penyembuhan Luka Bakar Buatan Pada Kelinci New Zealand. Jurnal Ilmiah Kesehatan Ar-Rum Salatiga, 6(2), 51–57. https://doi.org/10.36409/jika.v6i2.151

Prajayanti, E. D., Primaratri, S., Putri, A. H., Fitri, D., Utami, E., & Putri, D. A. (2024). Gudang Jurnal Multidisiplin Ilmu Peran Nutrisi Dalam Proses Penyembuhan Luka Di Bangsal Kultura RS Universitas Sebelas Maret. 2(November), 174–179.

Purba, G. S., Oktoba, Z., Soleha, T. U., & Adjeng, A. N. T. (2024). Sains Medisina. REVIEW: Efektivitas Daun Nangka Sebagai Antibakteri, 3(3), 22–28. https://wpcpublisher.com/jurnal/index.php/sainsmedisina/article/view/356

Rahmi, F., & Minerva, P. (2022). Kelayakan Daun Pandan Wangi Sebagai Masker Tradisional Perawatan Kulit Kering. Jurnal Tata Rias Dan Kecantikan, 3(2), 58. https://doi.org/10.24036/.v3i2.62

Rosyiedi, A. F. (2011). Uji Sifat Fisik dan Iritasi Sediaan Salep Ekstrak Etanolik Daun Pepaya (Carica papaya L.) Dengan Basis Hidrokarbon dan Absorbsi. Universitas Sebelas Maret Surakarta, 68.

Sandana, A., Jems Akiles Unitly, A., Eddy, L., Biologi Fakultas Matematika dan Ilmu Pengetahuan Alam, J., & Pattimura, U. (2020). The Effect of Administration Ethanol Extract Clove Leaf (Syzygium aromaticum L.) on The Improvement of Appetite and Body Weight of Rattus norvegicus. Biofaal Journal, 1(2), 2723–4959.

Sihotang, N. L., Idiawati, N., & Prayitno, D. I. (2022). Efektivitas Plester Luka Ekstrak Etanol Sargassum polycystum dan Padina australis terhadap Penyembuhan Luka Sayat. Jurnal Sosial Dan Sains, 2(2), 278–285. htp://sosains.greenvest.co.id.

Suena, N. M. D. S., Ariani, N. L. W. M., & Antari, N. P. U. (2022). Physical Evaluation and Hedonic Test of Sandalwood Oil (Santalum album L.) Cream as an Anti-Inflammatory. Jurnal Ilmiah Medicamento, 8(1), 22–30. https://doi.org/10.36733/medicamento.v8i1.3425

Suhartanto, K., Anggleri Julia, Y., & Evelyn Andreana, P. (2022). Uji Efektivitas Krim Ekstrak Etanol Bunga Kamboja (Plumeria sp. ) dalam Penyembuhan Ulkus Kaki pada Tikus yang Diinduksi Aloksan. Essence of Scientific Medical Journal, 20(1), 12–18.

Vella, F. M., Cautela, D., & Laratta, B. (2019). Characterization of polyphenolic compounds in cantaloupe melon by-products. Foods, 8(6), 2–11. https://doi.org/10.3390/foods8060196




DOI: https://doi.org/10.14421/biomedich.2025.141.225-231

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Copyright (c) 2025 Husna Rizki, Harlita



Biology, Medicine, & Natural Product Chemistry
ISSN 2089-6514 (paper) - ISSN 2540-9328 (online)
Published by Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity.

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