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The Comparison of Long-term Effect Between Intermittent Fasting and Calorie Restriction on Neurological Parameters of Mice
Abstract
Intermittent fasting (IF) and calorie restriction (CR) were purported to have health benefits. This research aimed to determine the long-term effect of IF and CR on selected neurological parameters in mice. Swiss Webster male mice were divided into 3 groups: ad libitum feeding (AL), IF, and CR. Mice in each group received the treatment for 16 weeks. They were then tested for anhedonia, depression, aggressiveness, and social approach. They were also subjected to contextual fear conditioning tests to model PTSD. Compared to AL, sucrose intake in the IF group was lower, while the CR group showed higher intake (p<0.01). This anhedonia characteristic shown in the IF group was confirmed not related to depression, as shown by significantly lower immobility time in the forced swimming test compared to AL (p<0.05). In the resident-intruder test, attack numbers in the IF group were fewer than in the AL group (p<0.05). As demonstrated by the results of the three-chamber test, the reduced aggressiveness in IF mice was unrelated to a deficit in sociability. In the fear extinction test (PTSD model), mice in the IF group showed lower freezing compared to those in AL (p<0.001). Although both IF and CR caused a reduction in total food intake, in the mice model tested, IF was shown to have favorable impacts on neurological parameters.
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Anson, R. M., Guo, Z., De Cabo, R., Iyun, T., Rios, M., Hagepanos, A., Ingram, D. K., Lane, M. A., & Mattson, M. P. (2003). Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake (Vol. 100, Issue 10). www.pnas.orgcgidoi10.1073pnas.1035720100
Bastani, A., Rajabi, S., & Kianimarkani, F. (2017). The effects of fasting during ramadan on the concentration of serotonin, dopamine, brainderived neurotrophic factor and nerve growth factor. Neurology International, 9(2), 29–33. https://doi.org/10.4081/ni.2017.7043
Carteri, R. B., Menegassi, L. N., Feldmann, M., Kopczynski, A., Rodolphi, M. S., Strogulski, N. R., Almeida, A. S., Marques, D. M., Porciúncula, L. O., & Portela, L. V. (2021). Intermittent fasting promotes anxiolytic-like effects unrelated to synaptic mitochondrial function and BDNF support. Behavioural Brain Research, 404. https://doi.org/10.1016/j.bbr.2021.113163
Cherif, A., Roelands, B., Meeusen, R., & Chamari, K. (2016). Effects of Intermittent Fasting, Caloric Restriction, and Ramadan Intermittent Fasting on Cognitive Performance at Rest and During Exercise in Adults. In Sports Medicine (Vol. 46, Issue 1, pp. 35–47). Springer International Publishing. https://doi.org/10.1007/s40279-015-0408-6
Cowen, P. J., & Browning, M. (2015). What has serotonin to do with depression? In World Psychiatry (Vol. 14, Issue 2, pp. 158–160). https://doi.org/10.1002/wps.20229
Dekkers, A. J., Miguel Amaya, J., van der Meulen, M., Biermasz, N. R., Meijer, O. C., & Pereira, A. M. (2022). Long-term effects of glucocorticoid excess on the brain. In Journal of Neuroendocrinology (Vol. 34, Issue 8). John Wiley and Sons Inc. https://doi.org/10.1111/jne.13142
Diagnostic and statistical manual of mental disorders : DSM-5TM. (5th edition.). (2013). [Book]. American Psychiatric Publishing, a division of American Psychiatric Association.
Dutta, S., & Sengupta, P. (2016). Men and mice: Relating their ages. In Life Sciences (Vol. 152, pp. 244–248). Elsevier Inc. https://doi.org/10.1016/j.lfs.2015.10.025
Elesawy, B. H., Raafat, B. M., Al Muqbali, A., Abbas, A. M., & Sakr, H. F. (2021). The Impact of Intermittent Fasting on Brain-Derived Neurotrophic Factor, Neurotrophin 3, and Rat Behavior in a Rat Model of Type 2 Diabetes Mellitus. https://doi.org/10.3390/brainsci
Göhler, L., Hahnemann, T., Michael, N., Oehme, P., Steglich, H. D., Conradi, E., Grune, T., & Siems, W. G. (2000). Reduction of plasma catecholamines in humans during clinically controlled severe underfeeding. Preventive Medicine, 30(2), 95–102. https://doi.org/10.1006/pmed.1999.0602
Gonidakis, S., Finkel, S. E., & Longo, V. D. (2010). Genome-wide screen identifies Escherichia coli TCA-cycle-related mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor ArcA. Aging Cell, 9(5), 868–881. https://doi.org/10.1111/j.1474-9726.2010.00618.x
Huether, G., Zhou, D., Schmidt, S., Wiltfang, J., & Rtither, E. (1997). Long-Term Food Restriction Down-Regulates the Density of Serotonin Transporters in the Rat Frontal Cortex.
Hwangbo, D. S., Lee, H. Y., Abozaid, L. S., & Min, K. J. (2020). Mechanisms of lifespan regulation by calorie restriction and intermittent fasting in model organisms. In Nutrients (Vol. 12, Issue 4). MDPI AG. https://doi.org/10.3390/nu12041194
Juruena, M. F., Bocharova, M., Agustini, B., & Young, A. H. (2018). Atypical depression and non-atypical depression: Is HPA axis function a biomarker? A systematic review. In Journal of Affective Disorders (Vol. 233, pp. 45–67). Elsevier B.V. https://doi.org/10.1016/j.jad.2017.09.052
Kim, B. H., Joo, Y., Kim, M. S., Choe, H. K., Tong, Q., & Kwon, O. (2021). Effects of intermittent fasting on the circulating levels and circadian rhythms of hormones. In Endocrinology and Metabolism (Vol. 36, Issue 4, pp. 745–756). Korean Endocrine Society. https://doi.org/10.3803/ENM.2021.405
Maren, S. (2008). Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: Cautions and caveats. In European Journal of Neuroscience (Vol. 28, Issue 8, pp. 1661–1666). https://doi.org/10.1111/j.1460-9568.2008.06485.x
Michalsen, A. (2010). Prolonged fasting as a method of mood enhancement in chronic pain syndromes: A review of clinical evidence and mechanisms. In Current Pain and Headache Reports (Vol. 14, Issue 2, pp. 80–87). https://doi.org/10.1007/s11916-010-0104-z
Mohamed Shawky, S., Orabi, S., Shoghy, K., Shawky, S. M., Zaid, A. M., Orabi, S. H., Shoghy, K. M., & Hassan, W. A. (2015). Effect of Intermittent Fasting on Brain Neurotransmitters, Neutrophils Phagocytic Activity, and Histopathological Finding in Some Organs in Rats. International Journal of Research Studies in Biosciences (IJRSB), 3(11), 38–45. www.arcjournals.org
Pinches, I. J. L., Pinches, Y. L., Johnson, J. O., Haddad, N. C., Boueri, M. G., Oke, L. M., & Haddad, G. E. (2022). Could “cellular exercise” be the missing ingredient in a healthy life? Diets, caloric restriction, and exercise-induced hormesis. In Nutrition (Vols. 99–100). Elsevier Inc. https://doi.org/10.1016/j.nut.2022.111629
Randy J. Nelson, & Silvana Chiavegatto. (2001). Molecular basis of aggression. TRENDS in Neurosciences, 24(12), 713–719.
Sabatino, F., Masoro, E. J., Mcmahan, C. A., & Kuhn, R. W. (1991). Assessment of the Role of the Glucocorticoid System in Aging Processes and in the Action of Food Restriction. In Journal of Gerontology: BIOLOGICAL SCIENCES (Vol. 46, Issue 5).
Shojaie, M., Ghanbari, F., & Shojaie, N. (2017). Intermittent fasting could ameliorate cognitive function against distress by regulation of inflammatory response pathway Intermittent fasting could ameliorate cognitive function against distress. Journal of Advanced Research, 8(6), 697–701. https://doi.org/10.1016/j.jare.2017.09.002
Shoji, H., Takao, K., Hattori, S., & Miyakawa, T. (2014). Contextual and cued fear conditioning test using a video analyzing system in mice. Journal of Visualized Experiments, 85. https://doi.org/10.3791/50871
Trepanowski, J. F., & Bloomer, R. J. (2010). The impact of religious fasting on human health. In Nutrition Journal (Vol. 9, Issue 1). https://doi.org/10.1186/1475-2891-9-57
Welton, S., Minty, R., Fcfp, C., O’driscoll, T., Fcfp, M. D., Willms, H., Rpn, D. P., Madden, S., Kelly, L., & Frrm, M. F. (n.d.). Intermittent fasting and weight loss Systematic review (Vol. 66).
DOI: https://doi.org/10.14421/biomedich.2024.131.199-204
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