The Antiviral Potential of Iranian Herbal Pharmacopoeia (IHP) on Herpes Simplex Viruses (HSV): A Review Article

Shahin Gavanji

Abstract


Herpes Simplex Viruses (HSV) viruses are highly contagious that commonly cause dermatitis, encephalitis, meningitis and genitourinary infections and also can lead to cervical cancer. For treatment of HSV infections, several physical methods and antiviral drugs are introduced, antiviral medications can also prevent or reduce outbreaks. The use of herbal medicine with antiviral effects attracted worldwide attentions. The aim of this review article is to introduce the Iranian Herbal Pharmacopoeia (IHP) with antiviral potential against two HSV serotypes and help to evaluate and develop the new drugs from natural sources. To provide this review, relevant articles in some authentic databases including PubMed, Web of Science, Science Direct, Scopus, Google Scholar and SID (scientific information database), from 1967 to April 2022 were collected, and selected botanicals from (IHP) with their scientific names and classifications and their outcome (CC50 and IC50) were introduced. In this review, scientific data regarding anti-herpetic activities of Iranian Herbal Pharmacopoeia (IHP) showed that 34 herbs from 17 families have antiviral potential to inhibit two HSV serotypes. According to families, Lamiaceae family has the highest percentage (29.41 %) of plants with antiviral activity against two HSV serotypes, also review of recent data showed that Salvia officinalis, Melissa officinalis, Securigera Securidaca, Hyssopus officinalis, Quercus brantii, Artemisia aucheri and Curcuma longa have remarkable antiviral activity against two HSV serotypes. Results of this review suggest that further research to identify and purify the bioactive compounds to determine the molecular mechanisms of action is needed.


Keywords


herpes simplex; herbal medicine; pharmacopoeia; antiviral; drugs

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References


Abdul, A. M., Mackeen, M. M., EI-Sharkawy, S. H., Abdul, H., Junainah, N. H., Ismail, N. H., Ahmad, F., & Lajis, M. (1996). Antiviral and cytotoxic activities of some plants used in Malaysian indigenous medicine. Pertanika Journal of Tropical Agricultural Science,19(2),129-136. http://psasir.upm.edu.my/id/eprint/3541/

Abdul, W. M., Hajrah, N. H., Sabir, J. S., Al-Garni, S. M., Sabir, M. J., Kabli, S.A., Saini, K. S., & Bora, R. S. (2018). Therapeutic role of Ricinus communis L. and its bioactive compounds in disease prevention and treatment. Asian Pacific Journal of Tropical Medicine, 11, 177-85. https://doi.org/10.4103/1995-7645.228431

Abolhassani, M. (2010). Antiviral activity of borage (Echium amoenum). Archives of medical science : AMS, 6(3), 366–369. https://doi.org/10.5114%2Faoms.2010.14256

Adams, K., Eliot, T., & Gerald, A. (2014). Extent of Use of Aloe vera Locally Extracted Products for Management of Ailments in Communities of Kitagata Sub-county in Sheema District, Western Uganda. International journal of sciences, basic and applied research, 15(1), 1–15. https://pubmed.ncbi.nlm.nih.gov/26855960

Afzal, M., Masood, R., Jan, G., Majid, A., Fiaz, M., Shah, A. H., Alam, J., Mehdi, F. S, Abbasi, F. M., Ahmad, H., Islam, M., & Inamullah, N. U. (2011). Efficacy of Avicennia marina (Forsk.) vierh. leaves extracts againts some atmospheric fungi. African Journal of Biotechnology, 10 (52), 10790-9. https://doi.org/10.5897/AJB10.2214

Akram, M., Tahir, I. M., Shah, S., Mahmood, Z., Altaf, A., Ahmad, K., Munir, N., Daniyal, M., Nasir, S., & Mehboob, H. (2018). Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review. Phytotherapy research: PTR, 32(5), 811–822. https://doi.org/10.1002/ptr.6024

Al-Megrin, W. A., AlSadhan, N. A., Metwally, D. M., Al-Talhi, R. A., El-Khadragy, M. F., & Abdel-Hafez, L. (2020). Potential antiviral agents of Rosmarinus officinalis extract against herpes viruses 1 and 2. Bioscience reports, 40(6), BSR20200992. https://doi.org/10.1042%2FBSR20200992

Alipour, G., Dashti, S., & Hosseinzadeh, H. (2014). Review of pharmacological effects of Myrtus communis L. and its active constituents. Phytotherapy research: PTR, 28(8), 1125–1136. https://doi.org/10.1002/ptr.5122

Allahverdiyev, A. M., Bagirova, M., Yaman, S., Koc, R. C., Abamor, E. S., Ates, S.C., Baydar, S. Y., Elcicek, S., Oztel, O. N. (2013). Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components. Elsevier; Amsterdam, The Netherlands, Development of new antiherpetic drugs based on plant compounds, pp, 245–259. https://doi.org/10.1016/B978-0-12-398539-2.00017-3

Álvarez, Á. L., Habtemariam, S., Abdel Moneim, A. E., Melón, S., Dalton, K. P., & Parra, F. (2015). A spiroketal-enol ether derivative from Tanacetum vulgare selectively inhibits HSV-1 and HSV-2 glycoprotein accumulation in Vero cells. Antiviral research, 119, 8–18. https://doi.org/10.1016/j.antiviral.2015.04.004

Alves, J. G., de Brito, R., & Cavalcanti, T. S. (2012). Effectiveness of Mentha piperita in the Treatment of Infantile Colic: A Crossover Study. Evidence-based complementary and alternative medicine : eCAM, 2012, 981352. https://doi.org/10.1155%2F2012%2F981352

Álvarez, D. M., Castillo, E., Duarte, L. F., Arriagada, J., Corrales, N., Farías, M. A., Henríquez, A., Agurto-Muñoz, C., & González, P. A. (2020). Current Antivirals and Novel Botanical Molecules Interfering With Herpes Simplex Virus Infection. Frontiers in microbiology, 11, 139. https://doi.org/10.3389%2Ffmicb.2020.00139

Amiri, M. S., & Joharchi, M. R. (2016). Ethnobotanical knowledge of Apiaceae family in Iran: A review. Avicenna journal of phytomedicine, 6(6), 621–635. https://doi.org/10.1007/s00217-006-0295-z

Ani, V., Varadaraj, M. C., Akhilender & Naidu, K. (2006). Antioxidant and antibacterial activities of polyphenolic compounds from bitter cumin (Cuminum nigrum L.). The journal European Food Research and Technology, 224, 109–15. https://doi.org/10.1007/s00217-006-0295-z

Anderson, N. W., Buchan, B. W., & Ledeboer, N. A. (2014). Light microscopy, culture, molecular, and serologic methods for detection of herpes simplex virus. Journal of clinical microbiology, 52(1), 2–8. https://doi.org/10.1128%2FJCM.01966-13

Armaka, M., Papanikolaou, E., Sivropoulou, A., & Arsenakis, M. (1999). Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1. Antiviral research, 43(2), 79–92. https://doi.org/10.1016/s0166-3542(99)00036-4

Astani, A., Navid, M. H., & Schnitzler, P. (2014). Attachment and penetration of acyclovir-resistant herpes simplex virus are inhibited by Melissa officinalis extract. Phytotherapy research: PTR, 28(10), 1547–1552. https://doi.org/10.1002/ptr.5166

Asai, D., & Nakashima, H. (2018). Pathogenic Viruses Commonly Present in the Oral Cavity and Relevant Antiviral Compounds Derived from Natural Products. Medicines (Basel, Switzerland), 5(4), 120. https://doi.org/10.3390%2Fmedicines5040120

Arabzadeh, A. M., Ansari-Dogaheh, M., Sharififar, F., Shakibaie, M., & Heidarbeigi, M. (2013). Anti herpes simplex-1 activity of a standard extract of Zataria multiflora Boiss. Pakistan journal of biological sciences : PJBS, 16(4), 180–184. https://doi.org/10.3923/pjbs.2013.180.184

Astani, A., Reichling, J., & Schnitzler, P. (2010). Comparative study on the antiviral activity of selected monoterpenes derived from essential oils. Phytotherapy research: PTR, 24(5), 673–679. https://doi.org/10.1002/ptr.2955

Astani, A., Reichling, J., & Schnitzler, P. (2012). Melissa officinalis extract inhibits attachment of herpes simplex virus in vitro. Chemotherapy, 58(1), 70–77. https://doi.org/10.1159/000335590

Bag, P., Chattopadhyay, D., Mukherjee, H., Ojha, D., Mandal, N., Sarkar, M. C., Chatterjee, T., Das, G., & Chakraborti, S. (2012). Anti-herpes virus activities of bioactive fraction and isolated pure constituent of Mallotus peltatus: an ethnomedicine from Andaman Islands. Virology journal, 9, 98. https://doi.org/10.1186/1743-422X-9-98

Bai, L., Zhang, H., Liu, Q., Zhao, Y., Cui, X., Guo, S., Zhang, L., Ho, C. T., & Bai, N. (2016). Chemical characterization of the main bioactive constituents from fruits of Ziziphus jujuba. Food & function, 7(6), 2870–2877. https://doi.org/10.1039/c6fo00613b

Baharfar, R., Azimi, R., & Mohseni, M. (2015). Antioxidant and antibacterial activity of flavonoid-, polyphenol- and anthocyanin-rich extracts from Thymus kotschyanus boiss & hohen aerial parts. Journal of food science and technology, 52(10), 6777–6783. https://doi.org/10.1007%2Fs13197-015-1752-0

Barnard, D. L., Huffman, J. H., Morris, J. L., Wood, S. G., Hughes, B. G., & Sidwell, R. W. (1992). Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus. Antiviral research, 17(1), 63–77. https://doi.org/10.1016/0166-3542(92)90091-i

Behbahani M. (2009). Anti-viral activity of the methanolic leaf extract of an Iranian medicinal plant “Hyssopus officinalis” against herpes simplex virus. The Journal of Medicinal Plants, 3, 1118-1125.

Ben-Amor, I., Musarra-Pizzo, M., Smeriglio, A., D'Arrigo, M., Pennisi, R., Attia, H., Gargouri, B., Trombetta, D., Mandalari, G., & Sciortino, M. T. (2021). Phytochemical Characterization of Olea europea Leaf Extracts and Assessment of Their Anti-Microbial and Anti-HSV-1 Activity. Viruses, 13(6), 1085. https://doi.org/10.3390/v13061085

Behbahani, M., Zadeh, M. S., & Mohabatkar, H. (2013). Evaluation of antiherpetic activity of crude extract and fractions of Avicenna marina, in vitro. Antiviral research, 97(3), 376–380. https://doi.org/10.1016/j.antiviral.2013.01.001

Behbahani, M., Sayedipour, S., Pourazar, A., & Shanehsazzadeh, M. (2014). In vitro anti-HIV-1 activities of kaempferol and kaempferol-7-O-glucoside isolated from Securigera securidaca. Research in pharmaceutical sciences, 9(6), 463–469.https://pubmed.ncbi.nlm.nih.gov/26339261

Behbahani, M., Shanehsazzadeh, M., Shokoohinia, Y., Soltani, M. (2013). Evaluation of anti-herpetic activity of methanol seed extract and fractions of Securigera securidacain vitro. The Journal of Antivirals & Antiretrovirals (JAA), 5, 72–76. http://dx.doi.org/10.4172/jaa.1000066

Ben-Shabat, S., Yarmolinsky, L., Porat, D., & Dahan, A. (2020). Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies. Drug delivery and translational research, 10(2), 354–367. https://doi.org/10.1007/s13346-019-00691-6

Behl, T., Rocchetti, G., Chadha, S., Zengin, G., Bungau, S., Kumar, A., Mehta, V., Uddin, M. S., Khullar, G., Setia, D., Arora, S., Sinan, K. I., Ak, G., Putnik, P., Gallo, M., & Montesano, D. (2021). Phytochemicals from Plant Foods as Potential Source of Antiviral Agents: An Overview. Pharmaceuticals (Basel, Switzerland), 14(4), 381. https://doi.org/10.3390%2Fph14040381

Béjaoui, A., Ben Salem, I., Rokbeni, N., M'rabet, Y., Boussaid, M., & Boulila, A. (2017). Bioactive compounds from Hypericum humifusum and Hypericum perfoliatum: inhibition potential of polyphenols with acetylcholinesterase and key enzymes linked to type-2 diabetes. Pharmaceutical biology, 55(1), 906–911. https://doi.org/10.1080/13880209.2016.1270973

Ben-Shabat, S., Yarmolinsky, L., Porat, D., & Dahan, A. (2020). Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies. Drug delivery and translational research, 10(2), 354–367. https://doi.org/10.1007/s13346-019-00691-6

Benassi-Zanqueta, É., Marques, C. F., Valone, L. M., Pellegrini, B. L., Bauermeister, A., Ferreira, I., Lopes, N. P., Nakamura, C. V., Dias Filho, B. P., Natali, M., & Ueda-Nakamura, T. (2019). Evaluation of anti-HSV-1 activity and toxicity of hydroethanolic extract of Tanacetum parthenium (L.) Sch.Bip. (Asteraceae). Phytomedicine : international journal of phytotherapy and phytopharmacology, 55, 249–254. https://doi.org/10.1016/j.phymed.2018.06.040

Benassi-Zanqueta, É., Marques, C. F., Nocchi, S. R., Dias Filho, B. P., Nakamura, C. V., & Ueda-Nakamura, T. (2018). Parthenolide Influences Herpes simplex virus 1 Replication in vitro. Intervirology, 61(1), 14–22. https://doi.org/10.1159/000490055

Binns, S. E., Hudson, J., Merali, S., & Arnason, J. T. (2002). Antiviral activity of characterized extracts from echinacea spp. (Heliantheae: Asteraceae) against herpes simplex virus (HSV-I). Planta medica, 68(9), 780–783. https://doi.org/10.1055/s-2002-34397

Bora, K. S., Arora, S., & Shri, R. (2011). Role of Ocimum basilicum L. in prevention of ischemia and reperfusion-induced cerebral damage, and motor dysfunctions in mice brain. Journal of ethnopharmacology, 137(3), 1360–1365. https://doi.org/10.1016/j.jep.2011.07.066

Bourne, K. Z., Bourne, N., Reising, S. F., & Stanberry, L. R. (1999). Plant products as topical microbicide candidates: assessment of in vitro and in vivo activity against herpes simplex virus type 2. Antiviral research, 42(3), 219–226. https://doi.org/10.1016/s0166-3542(99)00020-0

Bouhlal, R., Haslin, C., Chermann, J. C., Colliec-Jouault, S., Sinquin, C., Simon, G., Cerantola, S., Riadi, H., & Bourgougnon, N. (2011). Antiviral activities of sulfated polysaccharides isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales). Marine drugs, 9(7), 1187–1209. https://doi.org/10.3390/md9071187

Brezáni, V., Leláková, V., Hassan, S., Berchová-Bímová, K., Nový, P., Klouček, P., Maršík, P., Dall'Acqua, S., Hošek, J., & Šmejkal, K. (2018). Anti-Infectivity against Herpes Simplex Virus and Selected Microbes and Anti-Inflammatory Activities of Compounds Isolated from Eucalyptus globulus Labill. Viruses, 10(7), 360. https://doi.org/10.3390/v10070360

Burlou-Nagy, C., Bănică, F., Jurca, T., Vicaș, L. G., Marian, E., Muresan, M. E., Bácskay, I., Kiss, R., Fehér, P., & Pallag, A. (2022). Echinacea purpurea (L.) Moench: Biological and Pharmacological Properties. A Review. Plants (Basel, Switzerland), 11(9), 1244. https://doi.org/10.3390/plants11091244

Caruso, F., Rossi, M., Pedersen, J. Z., & Incerpi, S. (2020). Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone. Journal of infection and public health, 13(12), 1868–1877. https://doi.org/10.1016/j.jiph.2020.09.015

Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., & Chan, S. W. (2011). A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology, 19(5), 245–254. https://doi.org/10.1007/s10787-010-0062-4

Chang, S. J., Huang, S. H., Lin, Y. J., Tsou, Y. Y., & Lin, C. W. (2014). Antiviral activity of Rheum palmatum methanol extract and chrysophanol against Japanese encephalitis virus. Archives of pharmacal research, 37(9), 1117–1123. https://doi.org/10.1007%2Fs12272-013-0325-x

Catella, C., Camero, M., Lucente, M. S., Fracchiolla, G., Sblano, S., Tempesta, M., Martella, V., Buonavoglia, C., & Lanave, G. (2021). Virucidal and antiviral effects of Thymus vulgaris essential oil on feline coronavirus. Research in veterinary science, 137, 44–47. https://doi.org/10.1016/j.rvsc.2021.04.024

Chiang LC, Ng LT, Cheng PW, Chiang W, Lin CC. (2005). Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. Clinical and experimental pharmacology & physiology, 32(10), 811–816. https://doi.org/10.1111/j.1440-1681.2005.04270.x

Chang, S. J., Huang, S. H., Lin, Y. J., Tsou, Y. Y., & Lin, C. W. (2014). Antiviral activity of Rheum palmatum methanol extract and chrysophanol against Japanese encephalitis virus. Archives of pharmacal research, 37(9), 1117–1123. https://doi.org/10.1007%2Fs12272-013-0325-x

Chiang, L. C., Ng, L. T., Chiang, W., Chang, M. Y., & Lin, C. C. (2003). Immunomodulatory activities of flavonoids, monoterpenoids, triterpenoids, iridoid glycosides and phenolic compounds of Plantago species. Planta medica, 69(7), 600–604. https://doi.org/10.1055/s-2003-41113

Chiang, L. C., Chiang, W., Chang, M. Y., & Lin, C. C. (2003). In vitro cytotoxic, antiviral and immunomodulatory effects of Plantago major and Plantago asiatica. The American journal of Chinese medicine, 31(2), 225–234. https://doi.org/10.1142/s0192415x03000874

Chang, J. S., Wang, K. C., Yeh, C. F., Shieh, D. E., & Chiang, L. C. (2013). Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. Journal of ethnopharmacology, 145(1), 146–151. https://doi.org/10.1016/j.jep.2012.10.043

Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., & Lin, C. C. (2002). Antiviral activity of Plantago major extracts and related compounds in vitro. Antiviral research, 55(1), 53–62. https://doi.org/10.1016/s0166-3542(02)00007-4

Camero, M., Lanave, G., Catella, C., Capozza, P., Gentile, A., Fracchiolla, G., Britti, D., Martella, V., Buonavoglia, C., & Tempesta, M. (2019). Virucidal activity of ginger essential oil against caprine alphaherpesvirus-1. Veterinary microbiology, 230, 150–155. https://doi.org/10.1016/j.vetmic.2019.02.001

Chen, S. G., Leu, Y. L., Cheng, M. L., Ting, S. C., Liu, C. C., Wang, S. D., Yang, C. H., Hung, C. Y., Sakurai, H., Chen, K. H., & Ho, H. Y. (2017). Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid. Scientific reports, 7(1), 12264. https://doi.org/10.1038/s41598-017-12388-2

Chen, D., Su, A., Fu, Y., Wang, X., Lv, X., Xu, W., Xu, S., Wang, H., & Wu, Z. (2015). Harmine blocks herpes simplex virus infection through downregulating cellular NF-κB and MAPK pathways induced by oxidative stress. Antiviral research, 123, 27–38. https://doi.org/10.1016/j.antiviral.2015.09.003

Chuerduangphui, J., Nukpook, T., Pientong, C., Aromdee, C., Suebsasana, S., Khunkitti, W., So-In, C., Proyrungroj, K., & Ekalaksananan, T. (2022). Activity of 3,19-isopropylidinyl andrographolide against herpes simplex virus type 1 in an animal model. Antiviral chemistry & chemotherapy, 30, 20402066221089724. https://doi.org/10.1177/20402066221089724

Civitelli, L., Panella, S., Marcocci, M. E., De Petris, A., Garzoli, S., Pepi, F., Vavala, E., Ragno, R., Nencioni, L., Palamara, A. T., & Angiolella, L. (2014). In vitro inhibition of herpes simplex virus type 1 replication by Mentha suaveolens essential oil and its main component piperitenone oxide. Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(6), 857–865. https://doi.org/10.1016/j.phymed.2014.01.013

Cohen J. I. (2005). Licking latency with licorice. The Journal of clinical investigation, 115(3), 591–593. https://doi.org/10.1172%2FJCI24507

Crisci, E., Svanberg, C., Ellegård, R., Khalid, M., Hellblom, J., Okuyama, K., Bhattacharya, P., Nyström, S., Shankar, E. M., Eriksson, K., & Larsson, M. (2019). HSV-2 Cellular Programming Enables Productive HIV Infection in Dendritic Cells. Frontiers in immunology, 10, 2889. https://doi.org/10.3389/fimmu.2019.02889

Cui, Q., Du, R., Liu, M., & Rong, L. (2020). Lignans and Their Derivatives from Plants as Antivirals. Molecules (Basel, Switzerland), 25(1), 183. https://doi.org/10.3390%2Fmolecules25010183

Dadashi, M., Hashemi, A., Eslami, G., Fallah, F., Goudarzi, H., Erfanimanesh, S., & Taherpour, A. (2016). Evaluation of antibacterial effects of Zataria multiflora Boiss extracts against ESBL-producing Klebsiella pneumoniae strains. Avicenna journal of phytomedicine, 6(3), 336–343. https://pubmed.ncbi.nlm.nih.gov/27462557

Da Rosa Guimarães, T., Quiroz, C. G., Borges, C. R., de Oliveira, S. Q., de Almeida, M. T., Bianco, É. M., Moritz, M. I., Carraro, J. L., Palermo, J. A., Cabrera, G., Schenkel, E. P., Reginatto, F. H., & Simões, C. M. (2013). Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae). Marine drugs, 11(11), 4176–4192. https://doi.org/10.3390/md11114176

De Oliveira, A., Adams, S. D., Lee, L. H., Murray, S. R., Hsu, S. D., Hammond, J. R., Dickinson, D., Chen, P., & Chu, T. C. (2013). Inhibition of herpes simplex virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association, 52, 207–215. https://doi.org/10.1016/j.fct.2012.11.006

Deepika, G., Durgadevi, H., Narayan, R., Sudanthira, M., & Manickan, E. (2014). Anti-Herpes Simplex Viruses activity of Camellia sinensis, member of the family Theaceae (green tea). BMC Infectious Diseases, 14(Suppl 3), P47. https://doi.org/10.1186%2F1471-2334-14-S3-P47

Dias, M. M., Zuza, O., Riani, L. R., de Faria Pinto, P., Pinto, P., Silva, M. P., de Moraes, J., Ataíde, A., de Oliveira Silva, F., Cecílio, A. B., & Da Silva Filho, A. A. (2017). In vitro schistosomicidal and antiviral activities of Arctium lappa L. (Asteraceae) against Schistosoma mansoni and Herpes simplex virus-1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 94, 489–498. https://doi.org/10.1016/j.biopha.2017.07.116

Ebrahimi, E., Mousavi-Jazayeri, S., Rezaee, M., & Parsania, M. (2021). Antiviral Effects of Aloe vera (L.) Burm.f. and Ruta Graveolens L. Extract on Acyclovir-Resistant Herpes Simplex Virus Type 1. Journal of Medicinal plants and By-product, 10(1), 103-108. https://dx.doi.org/10.22092/jmpb.2021.352463.1286

Ekiert H. (2000). Medicinal plant biotechnology: the Apiaceae family as the example of rapid development. Die Pharmazie, 55(8), 561–567. https://pubmed.ncbi.nlm.nih.gov/10989831/

Elkousy, R. H., Said, Z., Abd El-Baseer, M. A., & Abu El Wafa, S. A. (2021). Antiviral activity of castor oil plant (Ricinus communis) leaf extracts. Journal of ethnopharmacology, 271, 113878. https://doi.org/10.1016/j.jep.2021.113878

Elad, S., Zadik, Y., Hewson, I., Hovan, A., Correa, M. E., Logan, R., Elting, L. S., Spijkervet, F. K., & Brennan, M. T. (2010). Viral Infections Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO). A systematic review of viral infections associated with oral involvement in cancer patients: a spotlight on Herpesviridea. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 18(8), 993–1006. https://doi.org/10.1007/s00520-010-0900-3

Ezema, C. A., Ezeorba, T., Aguchem, R. N., & Okagu, I. U. (2022). Therapeutic benefits of Salvia species: A focus on cancer and viral infection. Heliyon, 8(1), e08763. https://doi.org/10.1016/j.heliyon.2022.e08763

Farahani, M. (2013). Antiviral effect assay of aqueous extract of Echium amoenum-L against HSV-1. Zahedan Journal of Research in Medical Sciences, 15(8), 46-48.

Fathiazad, F., & Hamedeyazdan, S. (2011) A review on Hyssopus officinalis L. Composition and biological activities. African Journal of Pharmacy and Pharmacology. 2011;5:1959–1966.

Fani, M.M., Motamedifar, M., & Kordshouli, M.Z. (2015). In vitro assessment of the anti-viral effect of Curcumin longa on Herpes Simplex virus type 1. Journal of Biology and Today's World, 4(5),115–119. https://doi.org/10.15412/J.JBTW.01030701

Farahani, M. (2013). Inhibition of HSV-1 multiplication by five species of medicinal plants. The Journal of Microbiology, Biotechnology and Food Sciences, 3,69-71. https://office2.jmbfs.org/index.php/JMBFS/article/view/7079

Farahani, M. (2014). Anti-Herpes simplex virus effect of Camellia Sinesis, Echiumamoenum and Nerium oleander. Applied and Environmental Microbiology, 2(4),102-105. http://pubs.sciepub.com/jaem/2/4/3/index.html#

Farooq, A. V., & Shukla, D. (2012). Herpes simplex epithelial and stromal keratitis: an epidemiologic update. Survey of ophthalmology, 57(5), 448–462. https://doi.org/10.1016/j.survophthal.2012.01.005

Farahani M. (2017). Antiviral Effect Assay of Thymus Kotschyanus on HSV-1 Multiplication. Alborz University Medical Journal, 6 (4), 269-275. http://dx.doi.org/10.29252/aums.6.4.269

Feola, A., Mancuso, A., & Arcangeli, M. (2018). A Case of Herpes Simplex Virus-1 Encephalitis from a Medicolegal Point of View. Case reports in medicine, 2018, 3764930. https://doi.org/10.1155%2F2018%2F3764930

Flores, D., Lee, L., & Adams, S. (2016). Inhibition of Curcumin-Treated Herpes Simplex Virus 1 and 2 in Vero Cells. Advances in Microbiology, 6, 276-287. http://dx.doi.org/10.4236/aim.2016.64027

Fritz, D., Venturi, C. R., Cargnin, S., Schripsema, J., Roehe, P. M., Montanha, J. A., & von Poser, G. L. (2007). Herpes virus inhibitory substances from Hypericum connatum Lam., a plant used in southern Brazil to treat oral lesions. Journal of ethnopharmacology, 113(3), 517–520. https://doi.org/10.1016/j.jep.2007.07.013

Fukuchi, K., Okudaira, N., Adachi, K., Odai-Ide, R., Watanabe, S., Ohno, H., Yamamoto, M., Kanamoto, T., Terakubo, S., Nakashima, H., Uesawa, Y., Kagaya, H., & Sakagami, H. (2016). Antiviral and Antitumor Activity of Licorice Root Extracts. In vivo (Athens, Greece), 30(6), 777–785. https://doi.org/10.21873/invivo.10994

Fyfe, J, Keller, P, Furman, P, et al. (1978) Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl) guanine. The Journal of Biological Chemistry 253: 8721–8727. https://pubmed.ncbi.nlm.nih.gov/214430/

Gavanji, S. Sayedipour, S.S., Larki, B., Bakhtari, A. (2015). Antiviral activity of some plant oils against herpes simplex virus type 1 in Vero cell culture. Journal of Acute Medicine, 5:62–68. https://doi.org/10.1016/j.jacme.2015.07.001

Gavanji, S., & Larki, B. (2017). Comparative effect of propolis of honey bee and some herbal extracts on Candida albicans. Chinese journal of integrative medicine, 23(3), 201–207. https://doi.org/10.1007/s11655-015-2074-9

Gavanji, S., Mohammadi, E., Larki, B., & Bakhtari, A. (2014). Antimicrobial and cytotoxic evaluation of some herbal essential oils in comparison with common antibiotics in bioassay condition. Integrative medicine research, 3(3), 142–152. https://doi.org/10.1016/j.imr.2014.07.001

Gavanji, S., Zaker, S. R., Nejad, Z. G., Bakhtari, A., Bidabadi, E. S., & Larki, B. (2015). Comparative efficacy of herbal essences with amphotricin B and ketoconazole on Candida albicans in the in vitro condition. Integrative medicine research, 4(2), 112–118. https://doi.org/10.1016/j.imr.2015.01.003

George, A. K., & Anil, S. (2014). Acute herpetic gingivostomatitis associated with herpes simplex virus 2: report of a case. Journal of international oral health : JIOH, 6(3), 99–102. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4109238/

Ghaemi, A., Soleimanjahi, H., Gill, P., Arefian, E., Soudi, S., & Hassan, Z. (2009). Echinacea purpurea polysaccharide reduces the latency rate in herpes simplex virus type-1. infections. Intervirology, 52(1), 29–34. https://doi.org/10.1159/000212988

Ghanadian, M., Sadraei, H., & Cheraghi, Z. (2016). Spasmodic versus spasmolytic activities of Euphorbia spinidens extract on rat isolated uterus. Research in pharmaceutical sciences, 11(6), 491–496. https://doi.org/10.4103/1735-5362.194893

Ghasemi Dehkordi, N., Sajadi, S., Ghanadi, A., Amanzadeh, Y., Azadbakht, M., and Asghari, G.(2003). Iranian herbal pharmacopoeia (IHP). Hakim Research Journal, 6(3), 63–69.

Ghasemzadeh Rahbardar, M., & Hosseinzadeh, H. (2020). Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders. Iranian journal of basic medical sciences, 23(9), 1100–1112. https://doi.org/10.22038%2Fijbms.2020.45269.10541

Ghannad, M. S., Mohammadi, A., Safiallahy, S., Faradmal, J., Azizi, M., & Ahmadvand, Z. (2014). The effect of aqueous extract of Glycyrrhiza glabra on herpes simplex virus 1. Jundishapur Journal of Microbiology, 7(7), e11616. https://doi.org/10.5812%2Fjjm.11616

Ghorbani, A., & Esmaeilizadeh, M. (2017). Pharmacological properties of Salvia officinalis and its components. Journal of traditional and complementary medicine, 7(4), 433–440. https://doi.org/10.1016/j.jtcme.2016.12.014

Ghorani, V., Khazdair, M. R., Mirsadraee, M., Rajabi, O., & Boskabady, M. H. (2022). The effect of two-month treatment with Zataria multiflora on inflammatory cytokines, pulmonary function testes and respiratory symptoms in patients with chronic obstructive pulmonary disease (COPD). Journal of ethnopharmacology, 293, 115265. https://doi.org/10.1016/j.jep.2022.115265

Golestannejad, Z., Mohammadi, E., Motamedi, A., Gavanji, S., Fallah, N., Bagherie, S., Farzane, G., Safaripour, M., Vally, A., Mohammadi, M., Larki, B., Bakhtari, A. (2016). Chemical composition and antibacterial activity of some herbal essential oils against Streptococcus mutans. Future Natural Products, 2(1), 1-8. http://herbmed.skums.ac.ir/article_14287.html

Grzanna R, Lindmark L, Frondoza C, Ginger - A herbal medicinal product with broad anti-inflammatory actions, J Med Food, 2005, 8(2), 125-132. https://doi.org/10.1089/jmf.2005.8.125

Gursoy, U. K., Gursoy, M., Gursoy, O. V., Cakmakci, L., Könönen, E., & Uitto, V. J. (2009). Anti-biofilm properties of Satureja hortensis L. essential oil against periodontal pathogens. Anaerobe, 15(4), 164–167. https://doi.org/10.1016/j.anaerobe.2009.02.004

Hassan, S., Šudomová, M., Berchová-Bímová, K., Šmejkal, K., & Echeverría, J. (2019). Psoromic Acid, a Lichen-Derived Molecule, Inhibits the Replication of HSV-1 and HSV-2, and Inactivates HSV-1 DNA Polymerase: Shedding Light on Antiherpetic Properties. Molecules (Basel, Switzerland), 24(16), 2912. https://doi.org/10.3390/molecules24162912

Hassan, S., Berchová-Bímová, K., Šudomová, M., Malaník, M., Šmejkal, K., & Rengasamy, K. (2018). In Vitro Study of Multi-Therapeutic Properties of Thymus bovei Benth. Essential Oil and Its Main Component for Promoting Their Use in Clinical Practice. Journal of clinical medicine, 7(9), 283. https://doi.org/10.3390/jcm7090283

Hashmi, M. A., Khan, A., Hanif, M., Farooq, U., & Perveen, S. (2015). Traditional Uses, Phytochemistry, and Pharmacology of Olea europaea (Olive). Evidence-based complementary and alternative medicine: eCAM, 2015, 541591. https://doi.org/10.1155/2015/541591

Hamidpour, R., Hamidpour, S., Hamidpour, M., Shahlari, M., & Sohraby, M. (2014). Summer Savory: From the Selection of Traditional Applications to the Novel Effect in Relief, Prevention, and Treatment of a Number of Serious Illnesses such as Diabetes, Cardiovascular Disease, Alzheimer's Disease, and Cancer. Journal of traditional and complementary medicine, 4(3), 140–144. https://doi.org/10.4103/2225-4110.136540

Hao, D. C. (2019). Chapter 9. Biodiversity, Chemodiversity, and Pharmacotherapy of Thalictrum Medicinal Plants, Da-Cheng Hao (ed.). Pp. 261–296. https://doi.org/10.1016/C2017-0-01185-0

Hayati, R. F., Better, C. D., Denis, D., Komarudin, A. G., Bowolaksono, A., Yohan, B., & Sasmono, R. T. (2021). [6]-Gingerol Inhibits Chikungunya Virus Infection by Suppressing Viral Replication. BioMed research international, 2021, 6623400. https://doi.org/10.1155/2021/6623400

Herrmann, E. C., Jr, & Kucera, L. S. (1967). Antiviral substances in plants of the mint family (labiatae). 3. Peppermint (Mentha piperita) and other mint plants. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 124(3), 874–878. https://doi.org/10.3181%2F00379727-124-31874

Hung, P. Y., Ho, B. C., Lee, S. Y., Chang, S. Y., Kao, C. L., Lee, S. S., & Lee, C. N. (2015). Houttuynia cordata targets the beginning stage of herpes simplex virus infection. PloS one, 10(2), e0115475. https://doi.org/10.1371%2Fjournal.pone.0115475

Huan, C., Xu, Y., Zhang, W., Guo, T., Pan, H., & Gao, S. (2021). Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives in Liquorice. Frontiers in pharmacology, 12, 680674. https://doi.org/10.3389/fphar.2021.680674

Hu, R., Ku, B., Zhang, Y., Jia, Y., Yao, H., Duan, S. (2004) Antiviral activity of complex of Hypericum perforatum L extract and lysine hydrochloride on herpes virus. Chinese Journal of Clinical Pharmacology and Therapeutics, 9(2), 136-139.

Hudson, J., Vimalanathan, S., Kang, L., Amiguet, V. T., Livesey J., & Arnason, J. T. (2005) Characterization of antiviral activities in echinacea root preparations. Pharmaceutical Biology, 43(9),790-796. https://doi.org/10.1080/13880200500408491

Hitl, M., Kladar, N., Gavarić, N., & Božin, B. (2021). Rosmarinic Acid-Human Pharmacokinetics and Health Benefits. Planta medica, 87(4), 273–282. https://doi.org/10.1055/a-1301-8648

Hutterer, C., Milbradt, J., Hamilton, S., Zaja, M., Leban, J., Henry, C., Vitt, D., Steingruber, M., Sonntag, E., Zeitträger, I., Bahsi, H., Stamminger, T., Rawlinson, W., Strobl, S., & Marschall, M. (2017). Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity. Antiviral research, 143, 113–121. https://doi.org/10.1016/j.antiviral.2017.04.003

Karimi, A., Moradi, M. T., Saeedi, M., Asgari, S., & Rafieian-Kopaei, M. (2013). Antiviral activity of Quercus persica L.: High efficacy and low toxicity. Advanced biomedical research, 2, 36. https://doi.org/10.4103/2277-9175.109722

Ikeda, T., Yokomizo, K., Okawa, M., Tsuchihashi, R., Kinjo, J., Nohara, T., & Uyeda, M. (2005). Anti-herpes virus type 1 activity of oleanane-type triterpenoids. Biological & pharmaceutical bulletin, 28(9), 1779–1781. https://doi.org/10.1248/bpb.28.1779

Ikeda, K., Tsujimoto, K., Uozaki, M., Nishide, M., Suzuki, Y., Koyama, A. H., & Yamasaki, H. (2011). Inhibition of multiplication of herpes simplex virus by caffeic acid. International journal of molecular medicine, 28(4), 595–598. https://doi.org/10.3892/ijmm.2011.739

Isaacs, C. E., Wen, G. Y., Xu, W., Jia, J. H., Rohan, L., Corbo, C., Di Maggio, V., Jenkins, E. C., Jr, & Hillier, S. (2008). Epigallocatechin gallate inactivates clinical isolates of herpes simplex virus. Antimicrobial agents and chemotherapy, 52(3), 962–970. https://doi.org/10.1128/aac.00825-07

Jang, Y., Shin, J. S., Lee, M. K., Jung, E., An, T., Kim, U. I., Kim, K., & Kim, M. (2021). Comparison of Antiviral Activity of Gemcitabine with 2'-Fluoro-2'-Deoxycytidine and Combination Therapy with Remdesivir against SARS-CoV-2. International journal of molecular sciences, 22(4), 1581. https://doi.org/10.3390/ijms22041581

Jassim, S. A., & Naji, M. A. (2003). Novel antiviral agents: a medicinal plant perspective. Journal of applied microbiology, 95(3), 412–427. https://doi.org/10.1046/j.1365-2672.2003.02026.x

Jin, F., Zhuo, C., He, Z., Wang, H., Liu, W., Zhang, R., & Wang, Y. (2015). Anti-herpes simplex virus activity of polysaccharides from Eucheuma gelatinae. World journal of microbiology & biotechnology, 31(3), 453–460. https://doi.org/10.1007/s11274-015-1798-1

Johri R. K. (2011). Cuminum cyminum and Carum carvi: An update. Pharmacognosy reviews, 5(9), 63–72. https://doi.org/10.4103%2F0973-7847.79101

Karimian, M., Najafi, R., Jaimand, K., Hatami, F., Abbasi, N., & Jalali Ghalousangh, A. (2020). Extraction and Identification of phytochemicals in Iranian oak (Quercus brantii var. Persica) Collected in Arghavan Valley, Ilam County by HS-SPME and GC-MS. Journal of Medicinal plants and By-product, 9(Special), 81-86. https://dx.doi.org/10.22092/jmpb.2020.121754

Karimi, A., Moradi, M. T., Saeedi, M., Asgari, S., & Rafieian-Kopaei, M. (2013). Antiviral activity of Quercus persica L.: High efficacy and low toxicity. Advanced biomedical research, 2, 36. https://doi.org/10.4103/2277-9175.109722

Karimi, A., Mohammadi-Kamalabadi, M., Rafieian-Kopaei, M., Amjad, L., & Salimzadeh, I. (2016). Determination of antioxidant activity, phenolic contents and antiviral potential of methanol extract of Euphorbia spinidens Bornm (Euphorbiaceae). The Tropical Journal of Pharmaceutical Research, 15(4),759-764. https://doi.org/10.4314/tjpr.v15i4.13

Khalil, N., El-Jalel, L., Yousif, M., & Gonaid, M. (2020). Altitude impact on the chemical profile and biological activities of Satureja thymbra L. essential oil. BMC complementary medicine and therapies, 20(1), 186. https://doi.org/10.1186/s12906-020-02982-9

Karimi, A., Rafieian-Kopaei, M., Moradi, M. T., & Alidadi, S. (2017). Anti-Herpes Simplex Virus Type-1 Activity and Phenolic Content of Crude Ethanol Extract and Four Corresponding Fractions of Quercus brantii L Acorn. Journal of evidence-based complementary & alternative medicine, 22(3), 455–461. https://doi.org/10.1177%2F2156587216676421

Kaunda, J. S., & Zhang, Y. J. (2019). The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review. Natural products and bioprospecting, 9(2), 77–137. https://doi.org/10.1007/s13659-019-0201-6

Kaczmarek B. (2020). Tannic Acid with Antiviral and Antibacterial Activity as A Promising Component of Biomaterials-A Minireview. Materials (Basel, Switzerland), 13(14), 3224. https://doi.org/10.3390%2Fma13143224

Karamoddini, M. K, Emami, S. A, Ghannad, M. S., Sani, E. A, & Sahebkar, A. (2011). Antiviral activities of aerial subsets of Artemisia species against Herpes Simplex virus type 1 (HSV1) in vitro. Asian Biomedicine, 5 (1), 63-8. https://doi.org/10.5372/1905-7415.0501.007

Kesharwani, A., Polachira, S.K., Nair, R.T., Agarwal, A., Mishra, N.N., & Gupta, S.K. (2017). Anti-HSV-2 activity of Terminalia chebula Retz extract and its constituents, chebulagic and chebulinic acids. BMC Complementary and Alternative Medicine, 14; 17(1):110. https://doi.org/10.1186/s12906-017-1620-8

Klemow, K. M., Bartlow, A., Crawford, J., Kocher, N., Shah, J., & Ritsick, M. (2011). Medical Attributes of St. John’s Wort (Hypericum perforatum). In I. Benzie (Eds.) et. al., Herbal Medicine: Biomolecular and Clinical Aspects. (2nd ed.). CRC Press/Taylor & Francis. http://www.ncbi.nlm.nih.gov/books/nbk92750/

Koytchev, R., Alken, R. G., & Dundarov, S. (1999). Balm mint extract (Lo-701) for topical treatment of recurring herpes labialis. Phytomedicine: international journal of phytotherapy and phytopharmacology, 6(4), 225–230. https://doi.org/10.1016/s0944-7113(99)80013-0

Kłysik, K., Pietraszek, A., Karewicz, A., & Nowakowska, M. (2020). Acyclovir in the Treatment of Herpes Viruses - A Review. Current medicinal chemistry, 27(24), 4118–4137. https://doi.org/10.2174/0929867325666180309105519

Koch, C., Reichling, J., Schneele, J., & Schnitzler, P. (2008). Inhibitory effect of essential oils against herpes simplex virus type 2. Phytomedicine: international journal of phytotherapy and phytopharmacology, 15(1-2), 71–78. https://doi.org/10.1016/j.phymed.2007.09.003

Krishnan, R., & Stuart, P. M. (2021). Developments in Vaccination for Herpes Simplex Virus. Frontiers in microbiology, 12, 798927. https://doi.org/10.3389/fmicb.2021.798927

Kshirsagar, S. G., & Rao, R. V. (2021). Antiviral and Immunomodulation Effects of Artemisia. Medicina (Kaunas, Lithuania), 57(3), 217. https://doi.org/10.3390/medicina57030217

Kuo, Y. C., Lin, L. C., Tsai, W. J., Chou, C. J., Kung, S. H., & Ho, Y. H. (2002). Samarangenin B from Limonium sinense suppresses herpes simplex virus type 1 replication in Vero cells by regulation of viral macromolecular synthesis. Antimicrobial agents and chemotherapy, 46(9), 2854–2864. https://doi.org/10.1128/aac.46.9.2854-2864.2002

Kurokawa, M., Ochiai, H., Nagasaka, K., Neki, M., Xu, H., Kadota, S., Sutardjo, S., Matsumoto, T., Namba, T., & Shiraki, K. (1993). Antiviral traditional medicines against herpes simplex virus (HSV-1), poliovirus, and measles virus in vitro and their therapeutic efficacies for HSV-1 infection in mice. Antiviral research, 22(2-3), 175–188. https://doi.org/10.1016/0166-3542(93)90094-y

Koujah, L., Suryawanshi, R. K., & Shukla, D. (2019). Pathological processes activated by herpes simplex virus-1 (HSV-1). infection in the cornea. Cellular and molecular life sciences : CMLS, 76(3), 405–419. https://doi.org/10.1007%2Fs00018-018-2938-1

Kutluay, S. B., Doroghazi, J., Roemer, M. E., & Triezenberg, S. J. (2008). Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity. Virology, 373(2), 239–247. https://doi.org/10.1016/j.virol.2007.11.028

Kubin, A., Wierrani, F., Burner, U., Alth, G., & Grünberger, W. (2005). Hypericin--the facts about a controversial agent. Current pharmaceutical design, 11(2), 233–253. https://doi.org/10.2174/1381612053382287

Kuo, Y. C., Kuo, Y. H., Lin, Y. L., & Tsai, W. J. (2006). Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression. Antiviral research, 70(3), 112–120. https://doi.org/10.1016/j.antiviral.2006.01.011

Lal M., Chandraker S.K., Shukla R. Functional and Preservative Properties of Phytochemicals. Elsevier; Amsterdam, The Netherlands: 2020. Antimicrobial properties of selected plants used in traditional Chinese medicine; pp. 119–143. https://doi.org/10.1016/C2018-0-03991-2

Lai, W. L., Chuang, H. S., Lee, M. H., Wei, C. L., Lin, C. F., & Tsai, Y. C. (2012). Inhibition of herpes simplex virus type 1 by thymol-related monoterpenoids. Planta medica, 78(15), 1636–1638. https://doi.org/10.1055/s-0032-1315208

Leonard, S. S., Keil, D., Mehlman, T., Proper, S., Shi, X., & Harris, G. K. (2006). Essiac tea: scavenging of reactive oxygen species and effects on DNA damage. Journal of ethnopharmacology, 103(2), 288–296. https://doi.org/10.1016/j.jep.2005.09.013

Lee, S., Lee, H. H., Shin, Y. S., Kang, H., & Cho, H. (2017). The anti-HSV-1 effect of quercetin is dependent on the suppression of TLR-3 in Raw 264.7 cells. Archives of pharmacal research, 40(5), 623–630. https://doi.org/10.1007/s12272-017-0898-x

Li, A., Xie, Y., Qi, F., Li, J., Wang, P., Xu, S., & Zhao, L. (2009). Anti-virus effect of traditional Chinese medicine Yi-Fu-Qing granule on acute respiratory tract infections. Bioscience trends, 3(4), 119–123. https://pubmed.ncbi.nlm.nih.gov/20103834/

Li, Z., Li, L. J., Sun, Y., & Li, J. (2007). Identification of natural compounds with anti-hepatitis B virus activity from Rheum palmatum L. ethanol extract. Chemotherapy, 53(5), 320–326. https://doi.org/10.1159/000107690

Li, T., Liu, L., Wu, H., Chen, S., Zhu, Q., Gao, H., Yu, X., Wang, Y., Su, W., Yao, X., & Peng, T. (2017). Anti-herpes simplex virus type 1 activity of Houttuynoid A, a flavonoid from Houttuynia cordata Thunb. Antiviral research, 144, 273–280. https://doi.org/10.1016/j.antiviral.2017.06.010

Li, H., Zhou, C., Pan, Y., Gao, X., Wu, X., Bai, H., Zhou, L., Chen, Z., Zhang, S., Shi, S., Luo, J., Xu, J., Chen, L., Zheng, X., & Zhao, Y. (2005). Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus. Planta Medica 71, 1128–1133. https://doi.org/10.1055/s-2005-873169

Liu, S., Li, L., Tan, L., & Liang, X. (2019). Inhibition of Herpes Simplex Virus-1 Replication by Natural Compound Honokiol. Virologica Sinica, 34(3), 315–323. https://doi.org/10.1007/s12250-019-00104-5

Lin, C. W., Wu, C. F., Hsiao, N. W., Chang, C. Y., Li, S. W., Wan, L., Lin, Y. J., & Lin, W. Y. (2008). Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71. International journal of antimicrobial agents, 32(4), 355–359. https://doi.org/10.1016/j.ijantimicag.2008.04.018

Lin, L. T., Chen, T. Y., Chung, C. Y., Noyce, R. S., Grindley, T. B., McCormick, C., Lin, T. C., Wang, G. H., Lin, C. C., & Richardson, C. D. (2011). Hydrolyzable tannins (chebulagic acid and punicalagin) target viral glycoprotein-glycosaminoglycan interactions to inhibit herpes simplex virus 1 entry and cell-to-cell spread. Journal of virology, 85(9), 4386–4398. https://doi.org/10.1128/jvi.01492-10

Li, F., Song, X., Su, G., Wang, Y., Wang, Z., Jia, J., Qing, S., Huang, L., Wang, Y., Zheng, K., & Wang, Y. (2019). Amentoflavone Inhibits HSV-1 and ACV-Resistant Strain Infection by Suppressing Viral Early Infection. Viruses, 11(5), 466. https://doi.org/10.3390%2Fv11050466

Lyu, S. Y., Rhim, J. Y., & Park, W. B. (2005). Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro. Archives of pharmacal research, 28(11), 1293–1301. https://doi.org/10.1007/bf02978215

Mardani, M., Motamedifar, M., & Hoseinipour, R. (2012). A Study of the Antiviral Effect of the Essential oil of Zataria Multiflora Boiss on Herpes Simplex Type 1 in Vero Cell Culture. Journal of Dentistry, Shiraz University of Medical Sciences (JDSUMS), 13:s414-s420.

Mancini, D. A. P., Torres, R. P., Pinto, J. R., & Mancini-Filho, J. (2009). Inhibition of DNA virus: Herpes-1 (HSV-1) in cellular culture replication, through an antioxidant treatment extracted from rosemary spice. Brazilian Journal of Pharmaceutical Science, 45(1), 127-133. https://doi.org/10.1590/S1984-82502009000100016

Mahboubi M. (2016). Myrtus communis L. and its application in treatment of Recurrent Aphthous Stomatitis. Journal of ethnopharmacology, 193, 481–489. https://doi.org/10.1016/j.jep.2016.09.054

Ma, F., Shen, W., Zhang, X., Li, M., Wang, Y., Zou, Y., Li, Y., & Wang, H. (2016). Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-κB Deactivated Properties. Biological & pharmaceutical bulletin, 39(10), 1667–1674. https://doi.org/10.1248/bpb.b16-00401

Mazzanti, G., Battinelli, L., Pompeo, C., Serrilli, A. M., Rossi, R., Sauzullo, I., Mengoni, F., & Vullo, V. (2008). Inhibitory activity of Melissa officinalis L. extract on Herpes simplex virus type 2 replication. Natural product research, 22(16), 1433–1440. https://doi.org/10.1080/14786410802075939

Ma, L., & Yao, L. (2020). Antiviral Effects of Plant-Derived Essential Oils and Their Components: An Updated Review. Molecules (Basel, Switzerland), 25(11), 2627. https://doi.org/10.3390%2Fmolecules25112627

Ming, L. J., & Yin, A. C. (2013). Therapeutic effects of glycyrrhizic acid. Natural product communications, 8(3), 415–418. https://pubmed.ncbi.nlm.nih.gov/23678825/

Mieres-Castro, D., Ahmar, S., Shabbir, R., & Mora-Poblete, F. (2021). Antiviral Activities of Eucalyptus Essential Oils: Their Effectiveness as Therapeutic Targets against Human Viruses. Pharmaceuticals (Basel, Switzerland), 14(12), 1210. https://doi.org/10.3390/ph14121210

Mohamed, F. F., Anhlan, D., Schöfbänker, M., Schreiber, A., Classen, N., Hensel, A., Hempel, G., Scholz, W., Kühn, J., Hrincius, E. R., & Ludwig, S. (2022). Hypericum perforatum and Its Ingredients Hypericin and Pseudohypericin Demonstrate an Antiviral Activity against SARS-CoV-2. Pharmaceuticals (Basel, Switzerland), 15(5), 530. https://doi.org/10.3390/ph15050530

Majewska, A., & Mlynarczyk-Bonikowska, B. (2022). 40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?. International journal of molecular sciences, 23(7), 3431. https://doi.org/10.3390/ijms23073431

Miraj, S., Rafieian-Kopaei, & Kiani, S. (2017). Melissa officinalis L: A Review Study With an Antioxidant Prospective. Journal of evidence-based complementary & alternative medicine, 22(3), 385–394. https://doi.org/10.1177/2156587216663433

Mnif, S., & Aifa, S. (2015). Cumin (Cuminum cyminum L.) from traditional uses to potential biomedical applications. Chemistry & biodiversity, 12(5), 733–742. https://doi.org/10.1002/cbdv.201400305

Mohamadein, M. M., Farrag, R. M., & Mekawey, A. A. I. (2015). Antiviral and Antidermatophytic Activity of a Compound Extracted from Cuminum Cyminum Seeds. Biomedical and Pharmacology Journal (BPJ), 8(2), 573-580. https://dx.doi.org/10.13005/bpj/800

Motamedifar, M., Ghafari, N., & Talezadeh, S. (2010). The effect of cumin seed extracts against herpes simplex virus type 1 in vero cell culture. The Iranian Journal of Medical Sciences (IJMS), 35, 304-309. https://ijms.sums.ac.ir/article_39801.html

Moradi, M. T., Karimi, A., Rafieian-Kopaei, M., Kheiri, S., Saedi-Marghmaleki, M. (2011). The inhibitory effects of myrtle (Myrtus communis) extract on herpes simplex virus-1 replication in baby hamster kidney cells. Journal of Shahrekord University of Medical Sciences, 12(4), 54–61. http://78.39.35.44/article-1-441-en.html

Mohammadi-Kamalabadi, M., Karimi, A., Rafieian, M., Amjad, L. (2014). Phytochemical study and anti viral effect evaluation of methanolic extract with fractions of aerial parts of euphorbia spinidens. Journal of Babol University of Medical Sciences, 16(5), 25-34. http://eprints.skums.ac.ir/id/eprint/2149

Motamedifar, M., Nekooeian, A., & Moatari, A. (2015). The effect of hydroalcoholic extract of olive leaves against herpes simplex virus type 1. The Iranian Journal of Medical Sciences (IJMS), 32(4):222‐226. https://ijms.sums.ac.ir/article_39967.html

Monavari, S., ShamsiShahrabadi, M., Mortazkar, & P. (2008). The study of antiviral effects of glycyrrihzaglabra extract on HSV. The Journal of Medicinal Plants, 4: 81-86.

Mohan, S., Elhassan Taha, M. M., Makeen, H. A., Alhazmi, H. A., Al Bratty, M., Sultana, S., Ahsan, W., Najmi, A., & Khalid, A. (2020). Bioactive Natural Antivirals: An Updated Review of the Available Plants and Isolated Molecules. Molecules (Basel, Switzerland), 25(21), 4878. https://doi.org/10.3390/molecules25214878

Mukhtar, M., Arshad, M., Ahmad, M., Pomerantz, R. J., Wigdahl, B., & Parveen, Z. (2008). Antiviral potentials of medicinal plants. Virus research, 131(2), 111–120. https://doi.org/10.1016%2Fj.virusres.2007.09.008

Namazi, R., Zabihollahi, R., Behbahani, M., & Rezaei, A. (2013). Inhibitory Activity of Avicennia marina, a Medicinal Plant in Persian Folk Medicine, against HIV and HSV. The Iranian Journal of Pharmaceutical Research (IJPR), 12,435-443. https://pubmed.ncbi.nlm.nih.gov/24250619

Nance, C. L., Shearer, W. T. (2003). Is green tea good for HIV-1 infection?, Journal of Allergy and Clinical Immunology, 112, 851–853.

Najafian, Y., Hamedi, S. S., Farshchi, M. K., & Feyzabadi, Z. (2018). Plantago major in Traditional Persian Medicine and modern phytotherapy: a narrative review. Electronic physician, 10(2), 6390–6399. https://doi.org/10.19082%2F6390

Nikolić, M., & Stevović S. (2015). Family Asteraceae as a sustainable planning tool in phytoremediation and its relevance in urban areas. Urban Forestry and Urban Greening, 14, 782–789. https://doi.org/10.1016/j.ufug.2015.08.002

Nolkemper, S., Reichling, J., Stintzing, F. C., Carle, R., & Schnitzler, P. (2006). Antiviral effect of aqueous extracts from species of the Lamiaceae family against Herpes simplex virus type 1 and type 2 in vitro. Planta medica, 72(15), 1378–1382. https://doi.org/10.1055/s-2006-951719

Ogawa, K., Nakamura, S., Oguri, H., Ryu, K., Yoneda, T., & Hosoki, R. (2021). Effective Search of Triterpenes with Anti-HSV-1 Activity Using a Classification Model by Logistic Regression. Frontiers in chemistry, 9, 763794. https://doi.org/10.3389/fchem.2021.763794

Ohishi, K., Toume, K., Arai, M. A., Sadhu, S. K., Ahmed, F., Mizoguchi, T., Itoh, M., & Ishibashi, M. (2014). Ricinine: a pyridone alkaloid from Ricinus communis that activates the Wnt signaling pathway through casein kinase 1α. Bioorganic & medicinal chemistry, 22(17), 4597–4601. https://doi.org/10.1016/j.bmc.2014.07.027

Omidian, J., Sheikhi-Shooshtari, F., & Fazeli, M. (2014). Inhibitory Effect of Mentha Piperita Extracts against Herpes Simplex Virus Isolated from Eye Infection. The Iranian Journal of Virology, 8 (1), 35-41. http://journal.isv.org.ir/article-1-222-fa.html

Parvez, M. K., Ahmed, S., Al-Dosari, M. S., Abdelwahid, M., Arbab, A. H., Al-Rehaily, A. J., & Al-Oqail, M. M. (2021). Novel Anti-Hepatitis B Virus Activity of Euphorbia schimperi and Its Quercetin and Kaempferol Derivatives. ACS omega, 6(43), 29100–29110. https://doi.org/10.1021/acsomega.1c04320

Pareek, A., Suthar, M., Rathore, G. S., & Bansal, V. (2011). Feverfew (Tanacetum parthenium L.): A systematic review. Pharmacognosy reviews, 5(9), 103–110. https://doi.org/10.4103/0973-7847.79105

Patil, S. M., Ramu, R., Shirahatti, P. S., Shivamallu, C., & Amachawadi, R. G. (2021). A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn. Heliyon, 7(5), e07054. https://doi.org/10.1016/j.heliyon.2021.e07054

Pebody, R. G., Andrews, N., Brown, D., Gopal, R., De Melker, H., François, G., Gatcheva, N., Hellenbrand, W., Jokinen, S., Klavs, I., Kojouharova, M., Kortbeek, T., Kriz, B., Prosenc, K., Roubalova, K., Teocharov, P., Thierfelder, W., Valle, M., Van Damme, P., & Vranckx, R. (2004). The seroepidemiology of herpes simplex virus type 1 and 2 in Europe. Sexually transmitted infections, 80(3), 185–191. https://doi.org/10.1136/sti.2003.005850

Pesola, J. M., & Coen, D. M. (2007). In vivo fitness and virulence of a drug-resistant herpes simplex virus 1 mutant. The Journal of general virology, 88(Pt 5), 1410–1414. https://doi.org/10.1099/vir.0.82787-0

Pirvu, L., Nicorescu, I., Hlevca, C., Albu, B. & Nicorescu, V. (2017). Burdock (Arctium lappa) Leaf Extracts Increase the In Vitro Antimicrobial Efficacy of Common Antibiotics on Gram-positive and Gram-negative Bacteria. Open Chemistry, 15(1), 92-102.

Pluymers, W., Neamati, N., Pannecouque, C., Fikkert, V., Marchand, C., Burke, T. R., Jr, Pommier, Y., Schols, D., De Clercq, E., Debyser, Z., & Witvrouw, M. (2000). Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters. Molecular pharmacology, 58(3), 641–648. https://doi.org/10.1515/chem-2017-0012

Raesi Vanani, A., Mahdavinia, M., Kalantari, H., Khoshnood, S., & Shirani, M. (2019). Antifungal effect of the effect of Securigera securidaca L. vaginal gel on Candida species. Current medical mycology, 5(3), 31–35. https://doi.org/10.18502%2Fcmm.5.3.1744

Ranjbar, A., Khorami, S., Safarabadi, M., Shahmoradi, A., Malekirad, A. A., Vakilian, K., Mandegary, A., & Abdollahi, M. (2006). Antioxidant Activity of Iranian Echium amoenum Fisch & C.A. Mey Flower Decoction in Humans: A cross-sectional Before/After Clinical Trial. Evidence-based complementary and alternative medicine : eCAM, 3(4), 469–473. https://doi.org/10.1093%2Fecam%2Fnel031

Rajbhandari, M., Wegner, U., Jülich, M., Schöpke, T., & Mentel, R. (2001). Screening of Nepalese medicinal plants for antiviral activity. Journal of ethnopharmacology, 74(3), 251–255. https://doi.org/10.1016/s0378-8741(00)00374-3

Rezazadeh, F., Moshaverinia, M., Motamedifar, M., & Alyaseri, M. (2016). Assessment of Anti HSV-1 Activity of Aloe Vera Gel Extract: an In Vitro Study. Journal of Dentistry, Shiraz University of Medical Sciences, 17(1), 49-54. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4771053/

Reuven, N. B., Staire, A. E., Myers, R. S., & Weller, S. K. (2003). The herpes simplex virus type 1 alkaline nuclease and single-stranded DNA binding protein mediate strand exchange in vitro. Journal of virology, 77(13), 7425–7433. https://doi.org/10.1128/jvi.77.13.7425-7433.2003

Roy, S., Sukla, S., De, A., & Biswas, S. (2022). Non-cytopathic herpes simplex virus type-1 isolated from acyclovir-treated patients with recurrent infections. Scientific reports, 12(1), 1345. https://doi.org/10.1038/s41598-022-05188-w

Rouf, R., Uddin, S. J., Sarker, D. K., Islam, M. T., Ali, E. S., Shilpi, J. A., Nahar, L., Tiralongo, E., & Sarker, S. D. (2020). Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data. Trends in food science & technology, 104, 219–234. https://doi.org/10.1016/j.tifs.2020.08.006

Rolnik, A., & Olas, B. (2021). The Plants of the Asteraceae Family as Agents in the Protection of Human Health. International journal of molecular sciences, 22(6), 3009. https://doi.org/10.3390%2Fijms22063009

Saha, S., Navid, M. H., Bandyopadhyay, S. S., Schnitzler, P., & Ray, B. (2012). Sulfated polysaccharides from Laminaria angustata: Structural features and in vitro antiviral activities. Carbohydrate polymers, 87(1), 123–130. https://doi.org/10.1016/j.carbpol.2011.07.026

Sahoo, M., Jena, L., Rath, S. N., & Kumar, S. (2016). Identification of Suitable Natural Inhibitor against Influenza A (H1N1) Neuraminidase Protein by Molecular Docking. Genomics & informatics, 14(3), 96–103. https://doi.org/10.5808/gi.2016.14.3.96

Sadowski, L. A., Upadhyay, R., Greeley, Z. W., & Margulies, B. J. (2021). Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2. Viruses, 13(7), 1228. https://doi.org/10.3390%2Fv13071228

Santoyo, S., Jaime, L., García-Risco, M. R., Ruiz-Rodríguez, A., & Reglero, G. (2014). Antiviral Properties of Supercritical CO2 Extracts from Oregano and Sage. International Journal of Food Properties, 17:1150–1161. https://doi.org/10.1080/10942912.2012.700539

Sayedipour, S.S., Behbahani, M., Moshtaghian, S.J. (2012). Evaluation of Anti-Herpes Simplex Virus Type 2 (HSV-2) Activity of Methanol Extract of Securigera securidacain by Cell Culture Method. Genetics in the 3rd millennium, 10,2802-2809.

Schnitzler, P., Schön, K., & Reichling, J. (2001). Antiviral activity of Australian tea tree oil and eucalyptus oil against herpes simplex virus in cell culture. Die Pharmazie, 56(4), 343–347. https://pubmed.ncbi.nlm.nih.gov/11338678/

Schnitzler, P., Koch, C., & Reichling, J. (2007). Susceptibility of drug-resistant clinical herpes simplex virus type 1 strains to essential oils of ginger, thyme, hyssop, and sandalwood. Antimicrobial agents and chemotherapy, 51(5), 1859–1862. https://doi.org/10.1128/aac.00426-06

Schnitzler, P., Nolkemper, S., Stintzing, F. C., & Reichling, J. (2008). Comparative in vitro study on the anti-herpetic effect of phytochemically characterized aqueous and ethanolic extracts of Salvia officinalis grown at two different locations. Phytomedicine : international journal of phytotherapy and phytopharmacology, 15(1-2), 62–70. https://doi.org/10.1016/j.phymed.2007.11.013

Schuhmacher, A., Reichling, J., & Schnitzler, P. (2003). Virucidal effect of peppermint oil on the enveloped viruses herpes simplex virus type 1 and type 2 in vitro. Phytomedicine : international journal of phytotherapy and phytopharmacology, 10(6-7), 504–510. https://doi.org/10.1078/094471103322331467

Scarpa, A., & Guerci, A. (1982). Various uses of the castor oil plant (Ricinus communis L.). A review. Journal of ethnopharmacology, 5(2), 117–137. https://doi.org/10.1016/0378-8741(82)90038-1

Semple SJ, Pyke SM, Reynolds GD, Flower RL. In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus. Antiviral Research. 2001;49:169–178. https://doi.org/10.1016/s0166-3542(01)00125-5

Shen, M. X., Ma, N., Li, M. K., Liu, Y. Y., Chen, T., Wei, F., Liu, D. Y., Hou, W., Xiong, H. R., & Yang, Z. Q. (2019). Antiviral Properties of R. tanguticum Nanoparticles on Herpes Simplex Virus Type I In Vitro and In Vivo. Frontiers in pharmacology, 10, 959. https://doi.org/10.3389/fphar.2019.00959

Shamsabadipour, S., Ghanadian, M., Saeedi, H., Rahimnejad, M. R., Mohammadi-Kamalabadi, M., Ayatollahi, S. M., & Salimzadeh, L. (2013). Triterpenes and Steroids from Euphorbia denticulata Lam. With Anti-Herpes Symplex Virus Activity. Iranian journal of pharmaceutical research : IJPR, 12(4), 759–767. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3920720/

Sharifi-Rad, J., Salehi, B., Schnitzler, P., Ayatollahi, S. A., Kobarfard, F., Fathi, M., Eisazadeh, M., & Sharifi-Rad, M. (2017). Susceptibility of herpes simplex virus type 1 to monoterpenes thymol, carvacrol, p-cymene and essential oils of Sinapis arvensis L., Lallemantia royleana Benth. and Pulicaria vulgaris Gaertn. Cellular and molecular biology (Noisy-le-Grand, France), 63(8), 42–47. https://doi.org/10.14715/cmb/2017.63.8.10

Shemluck M. (1982). Medicinal and other uses of the Compositae by Indians in the United States and Canada. Journal of ethnopharmacology, 5(3), 303–358. https://doi.org/10.1016/0378-8741(82)90016-2

Shuangsuo, D., Zhengguo, Z., Yunru, C., Xin, Z., Baofeng, W., Lichao, Y., & Yan'an, C. (2006). Inhibition of the replication of hepatitis B virus in vitro by emodin. Medical science monitor : international medical journal of experimental and clinical research, 12(9), BR302–BR306. https://pubmed.ncbi.nlm.nih.gov/16940925/

Singh, N. A., Kumar, P., & Kumar, N. (2021). Spices and herbs: Potential antiviral preventives and immunity boosters during COVID‐19. Phytotherapy Research, 35(5), 2745-2757. https://doi.org/10.1002/ptr.7019

Singhal, K., Raj, N., Gupta, K., & Singh, S. (2017). Probable benefits of green tea with genetic implications. Journal of oral and maxillofacial pathology : JOMFP, 21(1), 107–114. https://doi.org/10.4103/0973-029x.203758

Smidling, D., Mitic-Culafic, D., Vukovic-Gacic, B., Simic, D., & Knezevic-Vukcevic, J. (2008). Evaluation of antiviral activity of fractionated extracts of Sage Salvia officinalis L (Lamiaceae). The Archives of Biological Sciences, 60,421–9. https://doi.org/10.2298/ABS0803421S

Soares, A. R., Abrantes, J. L., Lopes Souza, T. M., Leite Fontes, C. F., Pereira, R. C., de Palmer Paixão Frugulhetti, I. C., & Teixeira, V. L. (2007). In vitro antiviral effect of meroditerpenes isolated from the Brazilian seaweed Stypopodium zonale (Dictyotales). Planta medica, 73(11), 1221–1224. https://doi.org/10.1055/s-2007-981589

Sowbhagya H. B. (2013). Chemistry, technology, and nutraceutical functions of cumin (Cuminum cyminum L): an overview. Critical reviews in food science and nutrition, 53(1), 1–10. https://doi.org/10.1080/10408398.2010.500223

Stuart, P. M., & Keadle, T. L. (2012). Recurrent herpetic stromal keratitis in mice: a model for studying human HSK. Clinical & developmental immunology, 2012, 728480. https://doi.org/10.1155/2012/728480

Subramanian, R. P., & Geraghty, R. J. (2007). Herpes simplex virus type 1 mediates fusion through a hemifusion intermediate by sequential activity of glycoproteins D, H, L, and B. Proceedings of the National Academy of Sciences of the United States of America, 104(8), 2903–2908. https://doi.org/10.1073/pnas.0608374104

Sydiskis, R. J., Owen, D. G., Lohr, J. L., Rosler, K. H., & Blomster, R. N. (1991). Inactivation of enveloped viruses by anthraquinones extracted from plants. Antimicrobial agents and chemotherapy, 35(12), 2463–2466. https://doi.org/10.1128%2Faac.35.12.2463

Tada M., Okuno K., Chiba K., Ohnishi E., Yoshii T. Antiviral diterpens from Saliva officinialis. Phytochemistry. 1994;35:539–541. https://doi.org/10.1016/S0031-9422(00)94798-8

Tepe, B., & Cilkiz, M. (2016). A pharmacological and phytochemical overview on Satureja. Pharmaceutical biology, 54(3), 375–412. https://doi.org/10.3109/13880209.2015.1043560

Tenório, J.A., Dulciana, S., da Silva, T.M., da Silva, T.G., & Ramos, C.S. (2016). Solanum paniculatum root extract reduces diarrhea in rats. The Revista Brasileira de Farmacognosia, 26(3),375–378. https://doi.org/10.1016/j.bjp.2016.02.003

Terlizzi, M. E., Occhipinti, A., Luganini, A., Maffei, M. E., & Gribaudo, G. (2016). Inhibition of herpes simplex type 1 and type 2 infections by Oximacro(®), a cranberry extract with a high content of A-type proanthocyanidins (PACs-A). Antiviral research, 132, 154–164. https://doi.org/10.1016/j.antiviral.2016.06.006

Thompson K. D. (1998). Antiviral activity of Viracea against acyclovir susceptible and acyclovir resistant strains of herpes simplex virus. Antiviral research, 39(1), 55–61. https://doi.org/10.1016/s0166-3542(98)00027-8

Tolo, F. M., Rukunga, G. M., Muli, F. W., Njagi, E. N., Njue, W., Kumon, K., Mungai, G. M., Muthaura, C. N., Muli, J. M., Keter, L. K., Oishi, E., & Kofi-Tsekpo, M. W. (2006). Anti-viral activity of the extracts of a Kenyan medicinal plant Carissa edulis against herpes simplex virus. Journal of ethnopharmacology, 104(1-2), 92–99. https://doi.org/10.1016/j.jep.2005.08.053

Treml, J., Gazdová, M., Šmejkal, K., Šudomová, M., Kubatka, P., & Hassan, S. (2020). Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development. Viruses, 12(2), 154. https://doi.org/10.3390%2Fv12020154

Trujillo, J., Chirino, Y. I., Molina-Jijón, E., Andérica-Romero, A. C., Tapia, E., & Pedraza-Chaverrí, J. (2013). Renoprotective effect of the antioxidant curcumin: Recent findings. Redox biology, 1(1), 448–456. https://doi.org/10.1016/j.redox.2013.09.003

Tshilanda, D.D., Ngoyi, E.M., Kabengele, C.N., Matondo, A., Bongo, G.N., Inkoto, C.L., Mbadiko, C.M., Gbolo, B.Z., Lengbiye, E.M., Kilembe, J.T., Mwanangombo, D.T., Kasiama, G.N., Tshibangu, D.S., Ngbolua, K.N., & Mpiana, P.T. (2020). Ocimum Species as Potential Bioresources against COVID-19: A Review of Their Phytochemistry and Antiviral Activity. International Journal of Pathogen Research, 5(4), 42-54. https://doi.org/10.9734/ijpr/2020/v5i430143

Van Rossum, T. G., Vulto, A. G., de Man, R. A., Brouwer, J. T., & Schalm, S. W. (1998). Review article: glycyrrhizin as a potential treatment for chronic hepatitis C. Alimentary pharmacology & therapeutics, 12(3), 199–205. https://doi.org/10.1046/j.1365-2036.1998.00309.x

Valadares, Y. M., Brandão'a, G. C., Kroon, E. G., Filho, J. D., Oliveira, A. B., & Braga, F. C. (2009). Antiviral activity of Solanum paniculatum extract and constituents. Zeitschrift fur Naturforschung. C, Journal of biosciences, 64(11-12), 813–818. https://doi.org/10.1515/znc-2009-11-1210

Vaghela, D., Davies, E., Murray, G., Convery, C., & Walker, L. (2021). Guideline for the Management Herpes Simplex 1 and Cosmetic Interventions. The Journal of clinical and aesthetic dermatology, 14(6 Suppl 1), S11–S14. https://pubmed.ncbi.nlm.nih.gov/34976293

Vlase, L., Benedec, D., Hanganu, D., Damian, G., Csillag, I., Sevastre, B., Mot, A. C., Silaghi-Dumitrescu, R., & Tilea, I. (2014). Evaluation of antioxidant and antimicrobial activities and phenolic profile for Hyssopus officinalis, Ocimum basilicum and Teucrium chamaedrys. Molecules (Basel, Switzerland), 19(5), 5490–5507. https://doi.org/10.3390/molecules19055490

Wang, J., Prinz, R. A., Liu, X., & Xu, X. (2020). In Vitro and In Vivo Antiviral Activity of Gingerenone A on Influenza A Virus Is Mediated by Targeting Janus Kinase 2. Viruses, 12(10), 1141. https://doi.org/10.3390/v12101141

Wang, D., Bădărau, A. S., Swamy, M. K., Shaw, S., Maggi, F., da Silva, L. E., López, V., Yeung, A., Mocan, A., & Atanasov, A. G. (2019). Arctium Species Secondary Metabolites Chemodiversity and Bioactivities. Frontiers in plant science, 10, 834. https://doi.org/10.3389%2Ffpls.2019.00834

Wahab, S., Annadurai, S., Abullais, S. S., Das, G., Ahmad, W., Ahmad, M. F., Kandasamy, G., Vasudevan, R., Ali, M. S., & Amir, M. (2021). Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology. Plants (Basel, Switzerland), 10(12), 2751. https://doi.org/10.3390/plants10122751

Westh, H., Zinn, C. S., & Rosdahl, V. T. (2004). An international multicenter study of antimicrobial consumption and resistance in Staphylococcus aureus isolates from 15 hospitals in 14 countries. Microbial drug resistance (Larchmont, N.Y.), 10(2), 169–176. https://doi.org/10.1089/1076629041310019

Wei, Y. P., Yao, L. Y., Wu, Y. Y., Liu, X., Peng, L. H., Tian, Y. L., Ding, J. H., Li, K. H., & He, Q. G. (2021). Critical Review of Synthesis, Toxicology and Detection of Acyclovir. Molecules (Basel, Switzerland), 26(21), 6566. https://doi.org/10.3390/molecules26216566

Weber, N. D., Murray, B. K., North, J. A., & Wood, S. G. (1994). The Antiviral Agent Hypericin has in vitro Activity against HSV-1 Through Non-Specific Association with Viral and Cellular Membranes. Antiviral Chemistry and Chemotherapy, 83–90. https://doi.org/10.1177%2F095632029400500204

Wiart, C., Kumar, K., Yusof, M. Y., Hamimah, H., Fauzi, Z. M., & Sulaiman, M. (2005). Antiviral Properties of Ent-Labdene Diterpenes of Andrographis Paniculata Nees, Inhibitors of Herpes Simplex Virus Type 1. Phytotherapy Research, 19, 1069–1070. https://doi.org/10.1002/ptr.1765

Wölbling, R. H., & Leonhardt, K. (1994). Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 1(1), 25–31. https://doi.org/10.1016/s0944-7113(11)80019-x

Zaker, S., Gavanji, S., Sayedipour, S., Bakhtari, A., Shirani Bidabadi, E., Larki, B., Golestannejad, Z. (2014). The Effect of Some Herbal Essential oils on Pathogenic Bacteria. Journal of Ethno-Pharmaceutical Products, 1(2), 23-34. https://civilica.com/doc/1297168/

Zamanian, M., Noormohammadi, Z., Sharifi, Z., Akbarzadeh, T., & Bineshian, F. (2021). Comparison of spring and autumn Artemisia aucheri extracts in in inhibition of HSV- 1 virus replication. New Cellularand Molecular Biotechnology Journal, 11 (44),19-28. http://ncmbjpiau.ir/article-1-1416-en.html

Zamanian, M., Sharifi, Z., Noormohammadi, Z., Akbarzadeh, T., & Bineshian, F. (2021). Antiviral effect of Artemisia aucheri aqueous extract on UL46 and US6 genes of HSV-1. Antiviral therapy, 26(1-2), 43–48. https://doi.org/10.1177/13596535211039907

Zandi, K., Taherzadeh, M., Yaghoubi, R., Tajbakhsh, S., Rastian, Z., & Sartavi, K. (2009). Antiviral activity of Avicennia marina against herpes simplex virus type 1 and vaccine strain of poliovirus (An in vitro study). Journal of Medicinal Plants Research, 3,771-775.

Zhang, X., Xu, Y., Li, Y., Yuan, H., Liu, Z., & Zhang, T. (2022). Prevalence and correlates of Kaposi's sarcoma-associated herpesvirus and herpes simplex virus type 2 infections among adults: evidence from the NHANES III data. Virology journal, 19(1), 5. https://doi.org/10.1186/s12985-021-01731-9

Zannou, O., Pashazadeh, H., Ghellam, M., Ibrahim, S. A., & Koca, I. (2021). Extraction of Anthocyanins from Borage (Echium amoenum) Flowers Using Choline Chloride and a Glycerol-Based, Deep Eutectic Solvent: Optimization, Antioxidant Activity, and In Vitro Bioavailability. Molecules (Basel, Switzerland), 27(1), 134. https://doi.org/10.3390/molecules27010134

Zandi, K., Zadeh, M. A., Sartavim K., & Rastian, Z. (2007). Antiviral activity of aloe vera against herpes simplex virus type 2: an in vitro study. African Journal of Biotechnology, 6(15),1770-1773. http://dx.doi.org/10.5897/AJB2007.000-2276

Zalilawati, M.R., Andriani, Y., Shaari, K., Bourgougnon, N., Ali, A.M., Muhammad, T.S.T., & Mohamad, H. (2015). Induction of apoptosis and anti HSV-1 activity of 3-(Phenethylamino) demethyl(oxy)aaptamine from a Malaysian Aaptos aaptos. Journal of Chemical and Pharmaceutical Research, 7, 330–341.

Zakaryan, H., Arabyan, E., Oo, A., & Zandi, K. (2017). Flavonoids: promising natural compounds against viral infections. Archives of virology, 162(9), 2539–2551. https://doi.org/10.1007%2Fs00705-017-3417-y

Zandi, K., Ramedani, E., Mohammadi, K., Tajbakhsh, S., Deilami, I., Rastian, Z., Fouladvand, M., Yousefi, F., & Farshadpour, F. (2010). Evaluation of antiviral activities of curcumin derivatives against HSV-1 in Vero cell line. Natural product communications, 5(12), 1935–1938. https://pubmed.ncbi.nlm.nih.gov/21299124/

Zhu, W., Chiu, L. C., Ooi, V. E., Chan, P. K., & Ang, P. O., Jr (2006). Antiviral property and mechanisms of a sulphated polysaccharide from the brown alga Sargassum patens against Herpes simplex virus type 1. Phytomedicine : international journal of phytotherapy and phytopharmacology, 13(9-10), 695–701. https://doi.org/10.1016/j.phymed.2005.11.003

Zheng, M. S., & Lu, Z. Y. (1990). Antiviral effect of mangiferin and isomangiferin on herpes simplex virus. Chinese medical journal, 103(2), 160–165. https://pubmed.ncbi.nlm.nih.gov/2167819/

Zhang, H. L., Dai, L. H., Wu, Y. H., Yu, X. P., Zhang, Y. Y., Guan, R. F., Liu, T., & Zhao, J. (2014). Evaluation of hepatocyteprotective and anti-hepatitis B virus properties of Cichoric acid from Cichorium intybus leaves in cell culture. Biological & pharmaceutical bulletin, 37(7), 1214–1220. https://doi.org/10.1248/bpb.b14-00137

Zolfaghari, M.E., Salamian, P., Riazi, A., Khaksa, A. (1997) Clinical trial of efficacy of myrtle oil in the treatment of herpex simplex. he Iranian Journal of Medical Sciences (IJMS), 22(3),134-137. https://pesquisa.bvsalud.org/portal/resource/pt/emr-96075

Zrig, A. (2022). The Effect of Phytocompounds of Medicinal Plants on Coronavirus (2019-NCOV) Infection. Pharmaceutical chemistry journal, 55, 1080–1084. https://doi.org/10.1007/s11094-021-02540-8

Yang, Z., Liu, N., Huang, B., Wang, Y., Hu, Y., & Zhu, Y. (2005). Effect of anti-influenza virus of Arctigenin in vivo. Journal of Chinese medicinal materials, 28(11), 1012–1014. https://europepmc.org/article/med/16514891

Yang, W., Chen, X., Li, Y., Guo, S., Wang, Z., & Yu, X. (2020). Advances in pharmacological activities of terpenoids. Natural Product Communications, 15, 1934578X20903555. https://doi.org/10.1177%2F1934578X20903555




DOI: https://doi.org/10.14421/biomedich.2022.112.89-109

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Copyright (c) 2022 Shahin Gavanji



Biology, Medicine, & Natural Product Chemistry
ISSN 2089-6514 (paper) - ISSN 2540-9328 (online)
Published by Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity.

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