Liver and Renal Cell Damage Following Excess Bee Honey Consumption in Male Wistar Rat

Akpevwoghene Agbatutu, Jerome Ndudi Asiwe, Olusegun Gafar Adebayo

Abstract


Honey is a widely used natural product with several health benefits. However, there is paucity of information on its excessive usage. The present study investigated the effect of excess honey consumption on hepato-renal functions in male wistar rats. Twenty-eight adult male Wistar rats were selected into four groups (n=7) and treated with distilled water (control) and 1ml, 2ml and 3ml of honey respectively for 5 weeks. Thereafter, the animals were euthanised and blood as well as kidney and liver were collected for further studies. There was a significant increase in Creatinine, Bilirubin, Urea AST, ALP, total protein as well as a significant decrease in RBC, WBC, haemoglobin, lymphocyte and PCV. Histology of the liver and kidney revealed a significant degeneration and necrosis in a dose dependent manner. This study suggest that excess honey consumption causes liver and renal cellular damage as well as haematological alterations.

Keywords


Honey; Excess consumption; liver enzyme; electrolyte; renal function; haematological indices; histopathology

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References


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DOI: https://doi.org/10.14421/biomedich.2022.111.35-43

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Copyright (c) 2022 Akpevwoghene Agbatutu, Jerome Ndudi Asiwe, Olusegun Gafar Adebayo



Biology, Medicine, & Natural Product Chemistry
ISSN 2089-6514 (paper) - ISSN 2540-9328 (online)
Published by Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity.

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