Video-Otoendoscopic Assessment of Tympanic Membrane Recovery Duration After Valsalva Maneuver as a Simple Screening for Eustachian Tube Dysfunction in Allergic Rhinitis

Edi Handoko, Ahmad Dian Wahyudiono, Hendradi Surjotomo, Nanik Setijowati, Samuel Prasetyo

Abstract


Eustachian tube dysfunction (ETD) is commonly associated with allergic rhinitis (AR) due to inflammatory changes affecting the nasopharyngeal and Eustachian tube mucosa. This study aimed to analyze the relationship between tympanic membrane (TM) recovery duration after Valsalva maneuver and Eustachian tube function (ETF) assessed by video otoendoscopy and ETF tympanometry in patients with allergic rhinitis. An observational analytic cross-sectional study was conducted involving AR patients and healthy controls. Tympanic membrane movement after Valsalva maneuver was recorded using video otoendoscopy, and the duration required for the TM to return to its initial position was measured. ETF was evaluated using tympanometry during resting condition and Valsalva maneuver. Patients with AR demonstrated significantly shorter TM recovery duration compared with healthy controls (p<0.001). Significant differences were also observed in ETF tympanometry parameters between groups. TM recovery duration showed a strong correlation with the distance between resting and Valsalva tympanometric curves in both control (r=0.897; p<0.001) and AR groups (r=0.920; p<0.001). Video otoendoscopic assessment of TM recovery duration after Valsalva maneuver may serve as a simple complementary method for evaluating ETF in allergic rhinitis patients.


Keywords


allergic rhinitis; Eustachian tube dysfunction; tympanometry; tympanic membrane; Valsalva maneuver

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References


Alhazmi WA (2022) Eustachian tube dysfunction and allergic rhinitis in young adult population of Saudi Arabia: A prospective comparative study. International Journal of Health Sciences 6(S6):9470-9480. https://doi.org/10.53730/ijhs.v6nS6.12458

Alikodra HS (2000) Biodiversity for development of local autonomous government. In: Setyawan AD, Sutarno (eds) Toward Mount Lawu National Park; proceeding of national seminary and workshop on biodiversity conservation to protect and save germplasm in Java Island. Sebelas Maret University, Surakarta, Indonesia, 17-20 July 2000.

Alper CM, Teixeira MS, Kim JH, Douglas Swarts J (2017) Diagnostic accuracy of tubomanometry R value in detecting the Eustachian tube pressure equalizing function. European Archives of Oto-Rhino-Laryngology 274(4):1865-1872. https://doi.org/10.1007/s00405-016-4430-6

Alshawi Y, Ismail A, Almegil N, Almubarak Z (2018) The effect of Valsalva and Toynbee maneuvers on tympanometry parameters in normal and retracted tympanic membrane. Global Journal of Otolaryngology 14(4):555896. https://doi.org/10.19080/GJO.2018.14.555896

Arbanto B, Putra KP, Ardha MA (2018) Perbedaan tingkat keberhasilan 3 metode ekualisasi pada penyelam terlatih di lingkungan air tawar. Jurnal Keolahragaan 6(2):193-199. https://doi.org/10.21831/jk.v6i2.21560

Ars B, Dirckx J (2016) Eustachian tube function. Otolaryngologic Clinics of North America 49(5):1121-1133. https://doi.org/10.1016/j.otc.2016.05.003

Biadsee A, Fanadka F, Dagan O, Firas K, Nageris B (2021) Ostmann’s fat pad—does it really matter? Annals of Otology, Rhinology & Laryngology 130(2):173-176. https://doi.org/10.1177/0003489420943219

Beleskiene V, Lesinskas E, Januskiene V, Daunoraviciene K, Rauba D, Ivaska J (2016) Eustachian tube opening measurement by sonotubometry using perfect sequences for healthy adults. Clinical and Experimental Otorhinolaryngology 9(2):116-122. https://doi.org/10.21053/ceo.2015.00626

Bluestone CD (1983) Eustachian tube function: physiology, pathophysiology, and role of allergy in pathogenesis of otitis media. Journal of Allergy and Clinical Immunology 72(3):242-251. https://doi.org/10.1016/0091-6749(83)90027-1

Bluestone CD, Simons JP, Healy GB (2014) Ear and related structure. In: Bluestone and Stool’s Pediatric Otolaryngology. 5th ed. People’s Medical Publishing House, Shelton, Connecticut, pp 633-654.

Bousquet J, Anto JM, Bachert C, Baiardini I, Bosnic-Anticevich S, Walter Canonica G, Melén E, Palomares O, Scadding GK, Togias A, Toppila-Salmi S (2020) Allergic rhinitis. Nature Reviews Disease Primers 6(1):95. https://doi.org/10.1038/s41572-020-00227-0

Casale J, Shumway KR, Hatcher JD (2025) Physiology, Eustachian tube function. In: StatPearls [Internet]. StatPearls Publishing, Treasure Island, Florida. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532284/

Casselbrant ML, Bakaletz LO, Rosenfeld RM (2011) Toynbee phenomenon. In: Proceedings of the 10th International Symposium on Recent Advances in Otitis Media. New Orleans, Louisiana, USA, pp 38-39.

Canali I, Petersen Schmidt Rosito L, Siliprandi B, Giugno C, Selaimen da Costa S (2017) Assessment of Eustachian tube function in patients with tympanic membrane retraction and in normal subjects. Brazilian Journal of Otorhinolaryngology 83(1):50-58. https://doi.org/10.1016/j.bjorl.2016.01.010

Chan Y, Goddard JC (2016) Anatomy of the ear—Eustachian tube. In: K.J. Lee’s Essential Otolaryngology Head and Neck Surgery. 11th ed. McGraw Hill Education, New York, pp 227-228.

Chauhan B, Chauhan K (2013) A comparative study of Eustachian tube functions in normal and diseased ears with tympanometry and videonasopharyngoscopy. Indian Journal of Otolaryngology and Head & Neck Surgery 65(Suppl 3):468-476. https://doi.org/10.1007/s12070-011-0312-9

Chung JJ, Naples JG (2024) Patulous Eustachian tube: deep breath for a diagnosis. Ear, Nose & Throat Journal 103(10):617-618. https://doi.org/10.1177/01455613211051793

Dhingra PL, Dhingra S (2014) Assessment of hearing. In: Diseases of Ear, Nose, and Throat. 7th ed. Replica Press, Kundli, pp 26-27.

Edmonson A, Iwanaga J, Olewnik ?, Dumont AS, Tubbs RS (2022) The function of the tensor tympani muscle: a comprehensive review of the literature. Anatomy & Cell Biology 55(2):113-117. https://doi.org/10.5115/acb.21.032

Finkelstein Y, Talmi YP, Zohar Y, Laurian N (1988) Study of Toynbee phenomenon by combined intranasopharyngeal and tympanometric measurements. Annals of Otology, Rhinology & Laryngology 97(2 Pt 1):199-206. https://doi.org/10.1177/000348948809700220

Georgiev KP, Shopov NG (2020) Eustachian tube function test as a predictor of middle ear barotrauma. International Maritime Health 71(3):195-200. https://doi.org/10.5603/IMH.2020.0035

Han WG, Yoo J, Rah YC, Chang J, Im GJ, Song JJ, Chae SW, Jung HH, Choi J (2017) Analysis of Eustachian tube dysfunction by dynamic slow motion video endoscopy and Eustachian tube dysfunction questionnaire in chronic otitis media. Clinical and Experimental Otorhinolaryngology 10(4):315-320. https://doi.org/10.21053/ceo.2016.01683

Harju T, Kivekäs I, Numminen J, Rautiainen M (2017) Eustachian tube dysfunction-related symptoms in chronic nasal obstruction caused by inferior turbinate enlargement. Annals of Otology, Rhinology & Laryngology 126(12):798-803. https://doi.org/10.1177/0003489417735538

Heidsieck DSP, Smarius BJA, Oomen KPQ, et al. (2016) The role of the tensor veli palatini muscle in the development of cleft palate-associated middle ear problems. Clinical Oral Investigations 20:1389-1401. https://doi.org/10.1007/s00784-016-1828-x

Heinzerling L, Mari A, Bergmann KC, Bresciani M, Burbach G, Darsow U, Durham S, Fokkens W, Gjomarkaj M, Haahtela T, Bom AT, Wöhrl S, Maibach H, Lockey R (2013) The skin prick test—European standards. Clinical and Translational Allergy 3(1):3. https://doi.org/10.1186/2045-7022-3-3

Hidir Y, Ulus S, Karahatay S, Satar B (2011) A comparative study on efficiency of middle ear pressure equalization techniques in healthy volunteers. Auris Nasus Larynx 38(4):450-455. https://doi.org/10.1016/j.anl.2010.11.014

Ikeda R, Kawase T, Takata I, Suzuki Y, Sato T, Katori Y, Kobayashi T (2019) Width of patulous Eustachian tube: comparison of assessment by sonotubometry and tubo-tympano-aerography. Otology & Neurotology 40(4):e386-e392. https://doi.org/10.1097/MAO.0000000000002141

Ikeda R, Ohta S, Yoshioka S, Endo S, Lee K, Kikuchi T, Yoshida H, Inagaki A, Kaneko A, Kobayashi H, Yoshida N, Oshima T, Mizuta K, Morita M, Yamaguchi N, Takahashi H, Kobayashi T (2024) A manual of Eustachian tube function tests—illustration of representative test results obtained from healthy subjects and typical disorders with suggestion of the appropriate test method of choice. Auris Nasus Larynx 51(1):206-213. https://doi.org/10.1016/j.anl.2023.06.005

Juszczak HM, Loftus PA (2020) Role of allergy in Eustachian tube dysfunction. Current Allergy and Asthma Reports 20(10):54. https://doi.org/10.1007/s11882-020-00951-3

Jayadevan P, Raj P, Anand V, Singh K (2024) Prevalence of Eustachian tube dysfunction in patients with allergic rhinitis: an observational cross-sectional study. Journal of Marine Medical Society 26(2):253-257. https://doi.org/10.4103/jmms.jmms_109_23

Kaneko A, Hosoda Y, Doi T, Tada N, Iwano T, Yamashita T (2001) Tubal compliance—changes with age and in tubal malfunction. Auris Nasus Larynx 28(2):121-124. https://doi.org/10.1016/S0385-8146(00)00090-0

Kim HY (2025) Eustachian tube dysfunction in hearing loss: mechanistic pathways to targeted interventions. Biomedicines 13(11):2686. https://doi.org/10.3390/biomedicines13112686

Lazo-Sáenz JG, Galván-Aguilera AA, Martínez-Ordaz VA, Velasco-Rodríguez VM, Nieves-Rentería A, Rincón-Castañeda C (2005) Eustachian tube dysfunction in allergic rhinitis. Otolaryngology–Head and Neck Surgery 132(4):626-629. https://doi.org/10.1016/j.otohns.2005.01.029

Leuwer R (2016) Anatomy of the Eustachian tube. Otolaryngologic Clinics of North America 49(5):1097-1106. https://doi.org/10.1016/j.otc.2016.05.002

Ma Y, Liang M, Tian P, Liu X, Dang H, Chen Q, Zou H, Zheng Y (2020) Eustachian tube dysfunction in patients with house dust mite-allergic rhinitis. Clinical and Translational Allergy 10:30. https://doi.org/10.1186/s13601-020-00328-9

McCoul ED (2021) Unlearning the ABCs of tympanometry. Otolaryngology–Head and Neck Surgery 165(4):491-492. https://doi.org/10.1177/0194599821995828

Meyer MF, Korthäuer C, Jansen S, Hüttenbrink KB, Beutner D (2018) Analyzing Eustachian tube function in patients with symptoms of chronic Eustachian tube dysfunction by pressure chamber measurements. European Archives of Oto-Rhino-Laryngology 275(5):1087-1094. https://doi.org/10.1007/s00405-018-4938-z

Mikolajczak S, Meyer MF, Hahn M, Korthäuer C, Jumah MD, Hüttenbrink KB, Grosheva M, Luers JC, Beutner D (2015) Characterizing the active opening of the Eustachian tube in a hypobaric/hyperbaric pressure chamber. Otology & Neurotology 36(1):70-75. https://doi.org/10.1097/MAO.0000000000000575

Mondain M, Vidal D, Bouhanna S, Uziel A (1997) Monitoring Eustachian tube opening: preliminary results in normal subjects. Laryngoscope 107(10):1414-1419. https://doi.org/10.1097/00005537-199710000-00022

Nur Husna SM, Tan HT, Md Shukri N, Mohd Ashari NS, Wong KK (2022) Allergic rhinitis: a clinical and pathophysiological overview. Frontiers in Medicine 9:874114. https://doi.org/10.3389/fmed.2022.874114

Okiemutu AU, Kenner OO, Okolugbo N, Amina O, Obohwemu K (2024) Diagnostic accuracy of the ETDQ-7 in adults at University of Benin Teaching Hospital. The American Journal of Interdisciplinary Innovations and Research 6(12):30-50. https://doi.org/10.37547/tajiir/Volume06Issue12-05

Onusko E (2004) Tympanometry. American Family Physician 70(9):1713-1720.

Pagano AS, Smith CM, Titunick MB, Idso A, Ahmad M, Yu A, Chung K, Li K, Lee S, Laitman JT, Márquez S (2025) Muscular origins of the levator veli palatini muscle: documenting anatomical variation and resolving five centuries of conflicting accounts. The Anatomical Record. https://doi.org/10.1002/ar.70055

Parsel SM, Unis GD, Souza SS, Bartley H, Bergeron JM, Master AN, McCoul ED (2020) Interpretation of normal and abnormal tympanogram findings in Eustachian tube dysfunction. Otolaryngology–Head and Neck Surgery 164(6):1-8. https://doi.org/10.1177/0194599820965236

Piskad?o-Zborowska K, Go?ota K, D?aman N, Szczepa?ski D, Ziemska-Gorczyca M (2025) Obstructive Eustachian tube dysfunction—diagnosis and treatment: a review of current research. Polish Otorhinolaryngology Review 14(3):30-35. https://doi.org/10.5604/01.3001.0055.1709

Rahmawati, Punagi AQ, Savitri E (2008) Hubungan antara beratnya rinitis, tes cukit kulit, dan kadar imunoglobulin E tungau debu rumah pada pasien rinitis alergi di Makassar. The Indonesian Journal of Medical Science 1(1):1-9.

Restuti RD, Sriyana AA, Priyono H, Saleh RR, Alviandi W (2023) Validity and reliability of Eustachian tube dysfunction questionnaire (ETDQ-7) adaptation in Bahasa Indonesia. Oto Rhino Laryngologica Indonesiana 53(1):7-14. https://doi.org/10.32637/orli.v53i1.622

Rosmini, Suharyanto R, Surjotomo H (2016) Hubungan derajat adenoid menggunakan teknik nasoendoskopi dengan tekanan telinga tengah. Oto Rhino Laryngologica Indonesiana 46(2):102-109. https://doi.org/10.32637/orli.v46i2.157

Schröder S, Lehmann M, Korbmacher D, Sauzet O, Sudhoff H, Ebmeyer J (2015) Evaluation of tubomanometry as a routine diagnostic tool for chronic obstructive Eustachian tube dysfunction. Clinical Otolaryngology 40(6):691-697. https://doi.org/10.1111/coa.12451

Schröder S, Lehmann M, Sauzet O, Ebmeyer J, Sudhoff H (2015) A novel diagnostic tool for chronic obstructive Eustachian tube dysfunction—the Eustachian tube score. Laryngoscope 125(3):703-708. https://doi.org/10.1002/lary.24922

Small P, Keith PK, Kim H (2018) Allergic rhinitis. Allergy, Asthma & Clinical Immunology 14(Suppl 2):51. https://doi.org/10.1186/s13223-018-0280-7

Smith ME, Scoffings DJ, Tysome JR (2016) Imaging of the Eustachian tube and its function: a systematic review. Neuroradiology 58(6):543-556. https://doi.org/10.1007/s00234-016-1663-4

Smith ME, Bance ML, Tysome JR (2019) Advances in Eustachian tube function testing. World Journal of Otorhinolaryngology–Head and Neck Surgery 5(3):131-136. https://doi.org/10.1016/j.wjorl.2019.08.002

Staab WJ (2021) Risk factors associated with environmental pressure changes on tympanic membrane rupture and ear damage. Canadian Audiologist 8(5).

Tarabichi M, Najmi M (2015) Site of Eustachian tube obstruction in chronic ear disease. Laryngoscope 125(11):2572-2575. https://doi.org/10.1002/lary.25330

Toluhaha TT, Punagi AQ, Perkasa MF (2013) Hubungan tipe deviasi septum nasi klasifikasi Mladina dengan kejadian rinosinusitis dan fungsi tuba Eustachius. Oto Rhino Laryngologica Indonesiana 43(2):120-130. https://doi.org/10.32637/orli.v43i2.69

Tysome JR, Sudhoff H (2018) The role of the Eustachian tube in middle ear disease. Advances in Oto-Rhino-Laryngology 81:146-152. https://doi.org/10.1159/000485581

Wackym PA, Snow JB (2016) Eustachian tube dysfunction. In: Ballenger’s Otorhinolaryngology Head and Neck Surgery. 18th ed. People’s Medical Publishing House, Shelton, Connecticut, pp 708-733.

Wheatley LM, Togias A (2015) Clinical practice. Allergic rhinitis. New England Journal of Medicine 372(5):456-463. https://doi.org/10.1056/NEJMcp1412282

Wolber P, Meyer MF, Knesic K, Rink S, Jansen S, Klussmann JP, Grosheva M (2022) Prospective study on the Eustachian tube function during Frenzel maneuver in a hypobaric/hyperbaric pressure chamber. European Archives of Oto-Rhino-Laryngology 279(4):1843-1850. https://doi.org/10.1007/s00405-021-06888-1

Yu X, Zhang H, Zong S, Xiao H (2024) Allergy in pathogenesis of Eustachian tube dysfunction. World Allergy Organization Journal 17(1):100860. https://doi.org/10.1016/j.waojou.2023.100860

Yvonne C, Goddard JC (2016) Audiology. In: K.J. Lee’s Essential Otolaryngology Head and Neck Surgery. 11th ed. McGraw Hill Education, New York, pp 257-259.




DOI: https://doi.org/10.14421/biomedich.2026.152.2109-2115

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