Potential of Tithonia diversifolia Hemsley A. Gray (Kembang Bulan) Leaf Extract as Anti-Cancer Agents

Muflihah Rizkawati

Abstract


The main objective of this review is to explain the great potential of herbal plants as anticancer agents. Cancer is a disease caused by abnormal cell growth in the body. The high number of cancer incidents still become a global concern because of the high mortality rate. The treatments of cancer such as chemotherapy can cause serious side effects by killing the normal cells. This is the reason why it is necessary to develop an alternative treatment of cancer. I discussed a plant that is believed to has health benefit. Many studies have showed the positive effect of Tithonia diversifolia plant for health. After 2000, the researchers discovered a new potential through its cytotoxicity to neoplastic cells. This plant needs to be developed sustainably. However, in the future this plant might become an effective alternative to treat cancer with lower side effects.

Keywords


Tithonia diversifolia (Hemsley) A. Gray; Kembang bulan; Anticancer

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References


Aryan, H. 2018. The Role of Herbal Medicine as Anti-Cancer Medicine: From Claim to Truth. Golden Medical Journal, 7:e1179. DOI: 10.22086/gmj.v0i0.1179

American Cancer Society. 2021.Basis Cancer. https://www.cancer.org/cancer/cancer-basics.html

Babazadeh, A., Zeinali, M., Hamishehkar, H. 2018. Nano-Phytosome: A Developing Platform for Herbal Anti-Cancer Agents in Cancer Therapy. Bentham Science. 19: 170-180. 10.2174/1389450118666170508095250

Farias, A., Rodrigues, A., Martins, R., Rabelo, E., Farias, C., de Almeida, S. 2019. Chemical Characterization, Antioxidant, Cytotoxic and Microbiological Activities of the Essential Oil of Leaf of Tithonia Diversifolia (Hemsl) A. Gray (Asteraceae). Pharmaceutical. 12, 34; doi:10.3390/ph12010034

Gabule Ang, A., Enot, M., Baltazar, G., Alinapon, C., Buncales, E., Barbosa, G. 2019. Antioxidant and Cytotoxic Activity of the Leaf Ethanolic Extracts of Tithonia diversofilia and Gliricidia sepium from Bukidnon, Philippines. Asian Journal of Biological and Life Science. 8(1): 8-15. DOI: 10.5530/ajbls.2019.8.2

Gu, J., Gills, J., Park, E., Greenwood, E., Hawthorne, M., Axelrod, F., Chavez, P., Fong, H., Mehta, R., Pezzuto, J., Kinghorn, A. 2002. Sesquiterpenoids from Tithonia diversifolia with Potential Cancer Chemopreventive Activity. Journal Natural Products. 65: 532-536.

Hausman, D. 2019. What is Cancer?. Perspective in Biology and Medicine, 6(4): 778-784. DOI: https://doi.org/10.1353/pbm.2019.0046.

Hiransai, P., Tangpong, J., Kumbuar, C., Hoonheang, N., Rodpech, O., Sangsuk, P., Kajklangdon, U., Inkaow, W. 2016. Anti-nitric oxide production, anti-proliferation and antioxidant effects of the aqueous extract from Tithonia diversifolia. Asian Pacific Journal of Tropical Biomedicine. 6(11): 950–956. http://dx.doi.org/10.1016/j.apjtb.2016.02.002.

Infodatin. 2019. Beban Kanker di Indonesia. Kementrian Kesehatan Republik Indonesia.https://pusdatin.kemkes.go.id/download.php?file=download/pusdatin/infodatin/Infodatin-Kanker-2019.pdf

Lee, M., Liao, M., Tsai, Y., Chiu, K., Wen, H. 2011. Identification and Anti-Human Glioblastoma Activity of Tagitinin C from Tithonia diversifolia Methanolic Extract. Journal of Agricultural and Food Chemistry. 59:2347-2355. dx.doi.org/10.1021/jf105003n

Liao, M., Tsai, Y., Yang, C., Juang, C., Lee, M., Chang, L., Wen, H. 2012. Anti-human hepatoma Hep-G2 proliferative, apoptotic, and antimutagenic activity of tagitinin C from Tithonia diversifolia leaves. Journal Natural Medicine. DOI 10.1007/s11418-012-0652-0

Lu, M., Huang, H., Chiou, W., Huang, R. 2017. Induction of Apoptosis by Tithonia diversifolia in Human Hepatoma Cells. Pharmacognosy Magazine.; 13:702-706. DOI: 10.4103/0973-1296.218113.

Miranda, M., Varela, R., Torres, A., Molinillo, J., Gualtieri, S., Macias, F. 2015. Phytotoxins from Tithonia diversifolia. Journal Natural Products. DOI: 10.1021/acs.jnatprod.5b00040

Ranti, I., Wahyuningsih, M., Wirohadidjojo. 2018. The antifibrotic effect of isolate tagitinin C from tithonia diversifolia (Hemsley) A. Gray on keloid fibroblast cell. Pan African Medical Journal. 30:264. doi:10.11604/pamj.2018.30.264.9994

Tagne, A., Marino, F., Cosentino, M.2018. Tithonia diversifolia (Hemsl.) A. Gray as a medicinal plant: A comprehensive review of its ethnopharmacology, phytochemistry, pharmacotoxicology and clinical relevance. Journal of Ethnopharmacology. 220: 94-116. https://doi.org/10.1016/j.jep.2018.03.025

Wahyuningsih, M., Syarif, R., Suharmi, S., Murini, T., Saputra, F., Suryo, A. 2013. Selectivity Of Purified Extract From The Leaves Of Tithonia Diversifolia (Hemsley) A.Gray) Against Hela Cells. Traditional Medicine Journal. Vol. 18(1), p 22-28.

Wahyuningsih, M., Wirohadidjojo, Y., Hidayat, R., Sadid, A. 2015. Antifibrotic Effect of Standardized Ethanol Extract of Tithonia diversifolia (Hemsley) A. Gray on Keloid Fibroblasts. International Journal of Pharmacognosy and Phytochemical Research. 7(4); 642-647.

Wahyuningsih, M., Nugrahaningsih, D., Budiyanto, A.2019. Ethanolic Extract of Tithonia Diversifolia (Hemsley) A. Gray Inhibits Migration Activity and Decrease the Transforming Growth Factor-Beta1, Vegf Expression On Keloid Fibroblasts. Asian Journal of Pharmaceutical and Clinical Research. 12(1): 342-345. DOI: http://dx.doi.org/10.22159/ajpcr.2019.v12i1.29850

World Health Organization, 2021. Cancer. https://www.who.int/health-topics/cancer#tab=tab_1




DOI: https://doi.org/10.14421/biomedich.2021.102.87-91

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Copyright (c) 2021 Muflihah Rizkawati



Biology, Medicine, & Natural Product Chemistry
ISSN 2089-6514 (paper) - ISSN 2540-9328 (online)
Published by Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity.

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