Email this article 
Effect of Ethanol Extracts of Musa paradisiaca Fruit Pulp and Peels on Haematological Indices and Liver Enzymes of Experimental Rats
Abstract
Medicinal plants usage in traditional medicine has risen over the years. Musa paradisiaca has been reported that it possesses various therapeutic efficacies. This study is aimed at evaluating the effect of parts of the ethanol fruit extracts of Musa paradisiaca on haematological indices and serum liver enzymes. Thirty Wistar rats were grouped into five groups of six animals each which were administered 200 mg/kg and 400 mg/kg of Musa paradisiac fruit (MPF) pulp extract or peel extract. Haematological indices and liver enzymes were assayed for at the end of the 14-days experimental period. MPF pulp and MPF peel at 400 mg/kg showed a significant (P<0.05) increase in red cell count and haematocrit level as compared to the control. There was a non-significant (P>0.05) increase in haemoglobin concentration in the treated rats as compared to the control. There was also a non-significant (P>0.05) change in AST, ALT, and ALP level of the treated rats as compared to the control. Fruit pulp and peel of Musa paradisiaca improve erythrocytes count and haematocrit level, and they may not be associated with liver toxicity.
Keywords
Full Text:
PDFReferences
Agarwal PK, Singh A, Gaurav K, Goel S, Khanna HD, Goel RK (2009). Evaluation of wound healing activity of extracts of plantain banana (Musa sapientum var. paradisiaca) in rats. Indian J Exp Biol 47: 322-40.
Baker FI, Silverton RE, Pallister CJ (1998). Baker and Silvertons Introduction to Medical Laboratory Technology, 7th edition, Bounty Press Ltd, Nigeria, 339-373.
Basu D, Kulkarni R (2014). Overview of blood components and their preparation. Indian J Anaesth 58(5): 529-37.
Benzie IFF, Wachtel-Galor S (2011). Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition, CRC Press/Taylor & Francis, Boca Raton (FL).
Ekor M (2014). The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol 4:177.
Emudainohwo JOT, Erhirhie EO, Moke EG, Edje KE (2015). A Comprehensive Review on Ethno-Medicine, Phytochemistry and Ethnopharmacology of Chrysophyllum albidum. Journal of Advances in Medical and Pharmaceutical Sciences 3(4): 147-154
Ezekwesili CN, Ghasi S, Adindu CS, Mefoh NC (2014). Evaluation of the anti-ulcer property of aqueous extract of unripe Musa paradisiaca Linn. peel in Wistar rats. African Journal of Pharmacy and Pharmacology 8(39): 1006-1011.
Fagbemi JF, Ugoji E, Adenipekun T, Adelowotan O (2009). Evaluation of the antimicrobial properties of unripe banana (Musa sapientum L.), lemon grass (Cymbopogon citratus S.) and turmeric (Curcuma longa L.) on pathogens Afr J Biotechnol 8(7): 1176-1182.
Giannini EG, Testa R, Savarino V (2005). Liver enzyme alteration: a guide for clinicians. CMAJ 172(3): 367-79.
Issa MT, Agbon AN, Balogun SU, Mahdi O, Bobbo KA, Ayegbusi FO (2018). Hepatoprotective effect of methanol fruit pulp extract of Musa paradisiaca on carbon tetrachloride-induced liver toxicity in Wistar rats. J Exp Clin Anat 17: 1-7
Iweala EEJ, Obichi IC, Omotosho OE (2011). Biochemical and Histological Responses of Hepatotoxic Rats Fed Musa paradisiaca L. Supplemented Diet. Int J Pharmacol 7(4): 471-477.
Magalhães P, Appell H, Duarite J (2008). Involvement of advanced gyration and production pathogenesis of diabetes complication: The protective role of regular physical activity. Eur Rev Aging Phys Act 5: 17-29.
Mahomoodally MF (2013). Traditional Medicines in Africa: An Appraisal of Ten Potent African Medicinal Plants. Evid Based Complement Alternat Med, 617459.
McGill MR (2016). The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI J 15: 817-828.
Moke EG, Anachuna KK, Edje KE, Ojezele MO (2019). Hepatoprotective effect of methanol seed extract of Citrus tangerina on paracetamol-induced hepatotoxicity in Wistar rats.
Niger J Nat Prod Med, 2019, 23: 83-87.
Moke EG, Omorodion LI, Akpoguma HA, Imere P, Ahante E (2017). Anti-ulcerogenic Activity of Aqueous Extract of Unripe Fruit of Musa sapientum Linn in Combination with Vitamin C on Ulcer Induced Models in Experimental Rats. Eur J Med Plants 19(2): 1-6
Mondal H, Budh DP (2020). Hematocrit [Updated 2020 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542276/
Nayar NM. The bananas: botany, origin, dispersal. Hortic Rev, 2010, 36: 117–164.
Nirmala M, Girija K, Lakshman K, Divya T (2012). Hepatoprotective activity of Musa paradisiacal on experimental animal models. Asian Pac J Trop Biomed 2(1): 11-15.
Northrop-Clewes CA, Thurnham DI (2013). Biomarkers for the differentiation of anemia and their clinical usefulness. J Blood Med, 4: 11-22.
Ohlsson A, Aher SM (2006). Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev 3: CD004863.
Okafo SE, Moke EG, Obi CS (2019). Formulation and evaluation of anti-diabetic tablets containing aqueous extract of Moringa oleifera seeds. J Pharm Allied Sci 16(5): 3167-3176.
Onasanwo SA, Emikpe BO, Ajah AA, Elufioye TO (2013). Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents. Pharmacognosy Res 5(3): 173-8.
Oyeyinka BO, Afolayan AJ (2019). Comparative Evaluation of the Nutritive, Mineral, and Antinutritive Composition of Musa sinensis L. (Banana) and Musa paradisiaca L. (Plantain) Fruit Compartments. Plants (Basel) 8(12): 598.
Pari L, Murugan P (2004). Protective role of tetrahydrocurcumin against erythromycin estolate-induced hepatotoxicity. Pharmacol Res 49(5): 481-6.
Ramaiah SK (2011). Preclinical safety assessment: current gaps, challenges and approaches in identifying translatable biomarkers of drug-induced liver. Clin Laboratory Med 31: 161-72.
Reitman S, Frankel S (1957). A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. American J Clin Path 28: 56-63.
Rieger MA, Schroeder T (2012). Hematopoiesis” Cold Spring Harb Perspect Biol 4(12): a008250.
Roy AV (1970). Rapid method for determining alkaline phosphatase activity in serum with thymolphthalein monophosphate. Clin. Chem 21: 5.
Tietz NW (1976). Fundamental of clinical chemistry, 2nd edition, WB Saunders Co, Philadelphia, 411.
Uwaoma LA (2003). Sources of common medicinal plants used in Southern Nigeria. Sam Press, Enugu, 23.
Vilhena RO, Figueiredo ID, Baviera AM, Silva DB, Marson BM, Oliveira JA, Peccinini RG, Borges IK, Pontarolo R (2020). Antidiabetic activity of Musa x paradisiaca extracts in streptozotocin-induced diabetic rats and chemical characterization by HPLC-DAD-MS. J Ethnopharmacol 254: 112666.
White NJ (2018). Anaemia and malaria. Malar J 17: 371.
Yin X, Quan J, Kanazawa T (2008). Banana Prevents Plasma Oxidative Stress in Healthy Individuals. Plant Foods Hum Nutr 63: 71–76
Zhao Z, Chang J, Lin L, Tsan F, Chang H, Wu C. (2018). Comparison of the hepatoprotective effects of four endemic Cirsium species extracts from Taiwan on CCl4 induced acute liver damage in C57BL/6 mice. Int J Mol Sci 19(1329): 1 18.
DOI: https://doi.org/10.14421/biomedich.2021.101.67-71
Refbacks
- There are currently no refbacks.
Copyright (c) 2021 Emuesiri Goodies Moke, Emuesiri Kohworho Umukoro, Evelyn Tarela Ojugbeli, Theresa Ezedom, Tarela Melish Elias Daubry, Iziegbe Lisa Omorodion
Biology, Medicine, & Natural Product Chemistry |
|
