Email this article 
Isolation and Characterization of Sesquiterpenes from Stem Bark of Warburgia ugandensis Sprague
Abstract
Warburgia ugandensis Sprague is one of the medicinal plants traditionally used to treat a number of diseases like asthma, cough, diarrhea, common cold, stomachache and toothache in Ethiopia. However, there is still insufficient information on the isolation and evaluation of bioactive compounds from this plant species. Extraction, purification and isolation of the stem bark of this plant by dichloromethane and chloroform as solvents afforded two sesquiterpenes; namely, WU-1 (ugandensidial) and WU-2 (cinnamolide-3β-acetate) respectively. The structural elucidations of these bioactive compounds were accomplished by using a variety of spectroscopic methods (IR, UV and NMR). The spectroscopic results compared with the reported data in the literature.
Keywords
Full Text:
PDFReferences
Butler, M.S. (2004). The Role of Natural Product Chemistry in Drug Discovery. J Nat Prod., 67(12) 2141-2153. DOI: 10.1021/np040106y
Dagne, E. (2009). Natural Database for Africa (NDA) On CD-ROM. Version1. Addis Ababa, Ethiopia. http://www.chemnetethiopia.com.
Dharani, N., Rukunga, G., Yenesew A., Mbora A., Mwaura L., Dawson I.; Jamnadass R. (2008). Common Antimalarial Trees and Shrubs of East Africa.1st edition. World Agro-forestry Centre: Nairobi, Kenya. ISBN: 978-92-9059-238-9. DOI: 10.1016/j.phytochem.2005.07.018
Drage, S., Mitter, B., Muchugi, A., Trols, A., Jamnadass, R. H., Sessitsch, A., Hadacek, F. (2014). Antimicrobial drimane sesquiterpenes and their effect on endophyte communities in the medical tree Warburgia ugandensis. Front Microbiol. 5(13). DOI: 10.3389/fmicb.2014.00013
Geyid, A., Abebe, D., Debella, A., Makonnen, Z., Aberre, F., Teka, F., Kebede, T., Urga, K., Yersaw, K., Biza, T., Mariam, B.H., Guta. M. (2005). Screening of some medicinal plants of Ethiopia for their anti-macrobial properties and chemical profiles. J. Ethnopharmacol, 97, 421-427. DOI: 10.1016/j.jep.2004.08.021
Gómez, G. S., Pelacho, A., Gené, A., Capell, T., Christou, P. (2007). The genetic Manipulation of Medicinal and Aromatic Plants. Plant Cell Rep.,26, 1689-1715.DOI: 10.1007/s00299-007-0384-x
Karani, L. W., Tolo, F. M., Karanja, S.M., Khayeka, C. W. (2013). Safety and efficacy of Prunus africana and Warburgia ugandensis against induced asthma in BALB/c Mice. Eur. J. Med. Plants. 3(3) 345-368. DOI:10.9734/EJMP/2013/3669
Kioy, D., Gray, A. I., Waterman, P. G. (1990). A comparative study of the stem barks drimane sesquiterpenes and leaf volatile oils of W. ugandensis and W. stuhlmannii. Phytochemistry, 29(11) 3535–3538.DIO: 10.1016/0031-9422(90)85270-P
Maroyi, A. (2013). Warburgia salutaris (Bertol. f.) Chiov; A multi-use ethnomedicinal plant species. J. Med. Plant Res., 7(2) 53-60. DOI: 10.5897/JMPR12.1019
Maundu, P., Tengnas, B. (2005). Useful Trees and Shrubs for Kenya. World Agroforestry Centre Eastern and Central Africa Regional Programme (ICRAF-ECA), Nairobi, Kenya. ISBN 9966-70-8.
Mbwambo, Z. H., Erasto, P., Innocent, E., Masimba P. J. (2009). Antimicrobial and cytotoxic activities of fresh leaf extracts of Warburgia ugandensis. Tanzan. J. Health Res,11 (2) 75-78. http://dx.doi.org/10.4314/thrb.v11i2.45205
Mohammed G. R., Extraction, Isolation and Characterization of Natural Products from Medicinal Plants. International Journal of Basic Sciences and Applied Computing (IJBSAC)ISSN: 2394-367X, 2 (6) 2018
Muchugi, A., Muluvi, G. M., Kindt, R., Kadu, C. A. C., Simons, A. J., Jamnadass, R.H. (2008). Genetic structuring of important medicinal species of genus Warburgiaas revealed by AFLP analysis. Tree Genet Genomes, 4(4) 787-795. DOI: 10.1007/s11295-008-0151-3
Ngure, P. K., Tonui, W. K., Ingonga. J., Mutai, Ch., Kigondu, E., Ng’ang’a, Z., Rukunga, G., Kimutai, A. (2009). In vitro antileishmanial activity of extracts of Warburgia ugandensis (Canellaceae), a Kenyan medicinal plant. J. Med. Plants Res., 3(2)61-66. DOI 10.3923/rjmp.2009.61.68
Rabe, T., Van Staden, J. (2000). Isolation of an antibacterial sesquiterpenoid from Warburgia salutaris. J. Ethnopharmacol., 73(1-2) 171–174. DOI:10.1016/s0378-8741(00)00293-2
Rajab, M.S., Ndegwa, J.M. (2000). 11α-Hydroxymuzigadiolide, a novel drimane sesquiterpene from the stem barks of Warburgia ugandensis. Bull. Chem. Soc. Ethiop. 14(1) 45–49. ISSN 1011-3294
Rukutt, J. K., Ngigi, A. N., Ndalut, P. K. (2005). Evaluation of natural products as possible alternatives to methyl bromide in soil fumigation. J. Agri. Sci. Tech, 7(1) 41-52. DOI: 10.1016/j.phymed.2003.08.005
Saiprasanna, B., Manohar, B.S., Roja, R. Y., Prasanta, K. C., Rajeshree, P. (2012). Phytochemical investigation and study on antioxidant properties of Ocimumcanum hydro-alcoholic leaf extracts. J. Drug Deliv. Ther., 2(4) 122 -128. DOI:10.22270/jddt.v2i4.198
Sasidharan S., Chen Y., Saravanan D., Sundram K. M., Yoga L. L. (2011). Extraction, isolation and characterization of bioactive compounds from plants’ extracts. Afr J Tradit Complement Altern Med., 8(1) 1-10, DOI: 10.4314/ajtcam.v8i1.60483.
Sukirtha, K., Growther, L. (2012). Antibacterial, antifungal and phytochemical analysis of selected medicinal plants.J. Nat. Prod. Plant Resour., 2(6) 644-648. (http://scholarsresearchlibrary.com/archive.html)
Wube, A. A., Bucar, F., Gibbons, S., Asres, K., Rattray, L., Croft, S.L. (2010). Antiprotozoal activity of drimane and coloratane sesquiterpenes towards Trypanosoma brucei rhodesiense and Plasmodium falciparum in vitro. Phytother Res., 24(10) 1468-1472. DOI: 10.1002/ptr.3126
Wube, A. A., Bucar, F., Gibbons, S., Asres, K. (2005). Sesquiterpenes from Warburgia ugandensis and their antimycobacterial activity. Phytochemistry, 66(19) 2309-2315.
Xu, M., Litaudon, M., Krief, S., Martin, M., Kasenene, J., Kiremire, B., Dumontet, V., Guéritte, F. (2009). Ugandenial A, a new drimane-type sesquiterpenoid from Warburgia ugandensis. Molecules, 14(10) 3844-3850. DOI: 10.3390/molecules14103844
DOI: https://doi.org/10.14421/biomedich.2020.91.39-46
Refbacks
- There are currently no refbacks.
Copyright (c) 2020 Teshome Gonfa Hordofa
Biology, Medicine, & Natural Product Chemistry |
|
