Email this article 
The Potential of Chrysin of Oroxylum indicum L. to Induce Carbonic Anhydrase (CA) to Improve Cattle Fertility
Abstract
The Artificial Insemination (AI) aims to develop the potential of the cattle reproduction comprehensively. The success of AI results is highly dependent on the level of livestock fertility. Therefore, improv the quality and quantity of semen could be done by hormone induction. However, hormone prices are expensive. This problem could be overcome using alternative way with the natural compound containing chrysin which might has the same function. The purpose of the study was analyze the potential of chrysin compound from Bungli plant (Oroxylum indicum) as fertilizer of males through bioinformatics approach. Methods performed through data search by webserver with the following stages: (1) Pubchem, (2) Swiss (3) Target Prediction, (4) Uniprot, (5) Protein Data Bank and (6) docking software using PyRx, PyMOL and Discovery Studio. The results showed that the chrysin compound interact with carbonic anhydrase (CA) expressed from the testes of the cattle, through van der Waals and Pi-Alkyl bonds. Chrysin is effective as CA ligand inducers based on affinity bonds (-8.4 kcal/mole) and more negatively than flavonol as a control compound with binding affinity (-6.2 kcal/mol). This suggests that chrysin is an effective compound as a potential drug for improved livestock fertility.
Keywords
Full Text:
PDFReferences
Affandhy, L., Ratnawati, D., & Luthfy, M. 2017. Herbal Combination Effect on the Quality of Semen and Libido in Ongole Cattle Cross-breed. Trad. Med. J. Vol. 22(2), p 84-90 ISSN-p: 1410-5918 ISSN-e : 2406-9086
Afriani, T., Jaswandi., Defrinaldi.,& Satria, Y.E. 2014. Pengaruh Waktu Pemberian Gonadotropin Releasing Hormone (GnRH) terhadap Jumlah Korpus Luteum dan Kecepatan Timbulnya Berahi pada Sapi Pesisir. Jurnal Peternakan Indonesia. Vol. 16 (3). ISSN 1907-1760
Akhlaghi,A., Ahangari, Y.J., Navidshad, B., Pirsaraei, Z.A., Zhandi, M., & Deldar, H. 2014. Improvements in semen quality, sperm fatty acids, and reproductive performance in aged Cobb 500 breeder roosters fed diets containing dried ginger rhizomes (Zingiber officinale). Poult Sci, 93:1236e44.
Amin, A., Putra, K.S., Amin, I.F., Earlia, N., Maulina, D., Lukiati, B. & Lestari, U. 2018. Quercetin: the bioactive compound from Allium cepa L. as anti-inflammation based on in silico screening. Journal of Biology, Medicine, & Natural Product Chemistry, Vol. 7:1. Doi: 10.14421/biomedich.2018.71.27-31
Balittro, B.B.S. 2015. Tanaman Obat Sebagai Bahan Baku Jamu Fertilitas Sapi. Warta Penelitian dan Pengembangan Tanaman Industri. Badan Penelitian dan Pengembangan Pertanian Pusat Penelitian dan Pengembangan Perkebunan. Volume 21, Nomor 3, ISSN 0853 – 8204.
Brown, G.A., Vukovich, M.D., Martini, E.R., Kohut, M.L., Franke, W.D., Jackson, D.A. & King, D.S. 2001. Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. International Journal for Vitamin and Nutrition Research, 71 293–301.
Campbell, D.R., & Kurzer, M.S. 1993. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J Steroid Biochem Mol Biol, 46:381e8.
Ciftci, O., Ozdemir, I., Aydin, M., & Beytur, A. 2011. Beneficial effects of chrysin on the reproductive system of adult male rats. Journal Andrologia.
Cohen J.P., Hoffer, A.P. & Rosen S. 1976. CA localization in the epididymis and testis of the rat: histochemical and biochemical analysis. Biol Reprod, 14: 339-346.
Deb, D., Datta, B. K., Debbarma, J., & Deb, S. 2016. Ethno-medicinal plants used for herbal medication of jaundice by the indigenous community of Tripura, India. Journal BIODIVERSITAS. Volume 17, Number 1, April 2016. Pages: 256-259. ISSN: 1412-033X. E-ISSN: 2085-4722. DOI: 10.13057/biodiv/d170137.
Deka, D. C., Kumar, V., Prasad, C., Kumar, K., Gogoi, B. J., Singh, L., & Srivastava, R. B. 2013. Oroxylum indicum– a medicinal plant of North East India: An overview of its nutritional, remedial, and prophylactic properties. Journal of Applied Pharmaceutical Science Vol. 3 (Suppl 1), pp. S104-S112, May, 2013. DOI: 10.7324/JAPS.2013.34.S19. ISSN 2231-3354.
Dhawan K, Kumar S & Sharma A. 2002 Beneficial effects of chrysin and benzoflavone on virility in 2-year-old male rats. Journal of Medicinal Food, 5: 43–48.
Direktorat Pangan dan Pertanian. 2010. Naskah Kebijakan (Policy Paper) Strategi dan Kebijakan dalam Percepatan Pencapaian Swasembada Daging Sapi 2014. Kementerian Perencanaan Pembangunan Nasional/ Badan Perencanaan Pembangunan Nasional (BAPPENAS).
Djarwaningsih, T. 1992. Oroxylum indicum (L.) Vent. Dalam: Rifai, M.A., Rugayah, dan E.A. Widjaja (Penyunting). Tiga Puluh Tumbuhan Obat Langka Indonesia. Floribunda, 2:19-20.
Edgren, R.A., Knudsen, K.A. & Jones, R.C .1971. On the role of CA in reproductive processes. J Reprod Fertil, 27:301-302.
Eid Y, Ebeid T, Younis H. 2006. Vitamin E supplementation reduces dexamethasoneinduced oxidative stress in chicken semen. Br Poult Sci, 47:350e6.
Ekstedt, E., Ridderstråle, Y., Plöen, L & Rodriguez-Martinez, H. 1991. Histochemical localization of CA in the testis and epididymis of the boar. Acta Anat 141:257-261.
Fisher, M.I., Tikkala, A.O. & Mawson, C.A. 1955. Zinc, CA and phosphatase in the prostatic glands of the rat. Can J Biochem Physiol, 33:181-190.
Foote, R.H. 1999. Development of reproductive biotechnologies in domestic animals from artificial insemination to cloning: A Perspective. Cloning, 1 (3):133-142.
Goyal, H.O., Ferguson, J.G. & Hrudka, F. 1980 Histochemical activity of CA in testicular and excurrent ducts of immature, mature intact and androgen-deprived bulls. Biol Reprod 22:991-997.
Harris, G. C., & Goto, K. 1984. CA activity of the reproductive tract tissues of aged male fowls and its relationship to semen production. Journal Reproduction Fertilization. Vol (70), 25 – 30.
Hewett-Emmet, D. 2000. Evolution and distribution of the CA gene families. In: Chegwidden WR, Carter ND & Edwards YH (eds) The CAs: New Horizons. Birkhäuser Verlag Basel, Switzerland, p 29-76.
Islam, M.K., Eti, Z.I., & Chowdhury, J.A. 2010. Phytochemical and Antimicrobial analysis on the extract of Oroxylum indicum (linn.) stembark. Iranian J Pharma & Therap, 9(1): 25-28.
Jana, K., Yin, X., Schiffer, R.B., Chen, J.J., Pandey, A.K., & Stocco, D.M. 2008. Chrysin, a natural flavonoid enhances steroidogenesis and steroidogenic acute regulatory protein gene expression in mouse Leydig cells. J Endocrinol,197: 315e23.
Kalaivani T. & Mathew L. 2009. Phytochemistry and Free radical scavenging activities of Oroxylum indicum . Environ We Int J Sci Tech.,4: 45-52.
Khandhar M., Shah M., Santani D., & Jain S. 2006. Antiulcer activity of the root bark of Oroxylum indicum against experimental gastric ulcers. Pharma boil., 44: 363-370.
Kharkar, P., Warrier, S., & Gaud, R. 2014. Reverse Docking: A Powerful Tool For Drug Repositioning And Drug Rescue. Future Medicinal Chemistry. 6 (3): 333-342.
Kumar V., Chaurasia A.K., Naglot A., Gopalakrishnan R., Gogoi B. J., Singh L., Srivastava R. B., & Deka D.C. 2011. Antioxidant and antimicrobial activities of stem bark extracts of Oroxylum indicum Vent. (Bignoniaceae) – A medicinal plant of northeastern India. South Asian J Exper Biol., 1(3):152-157.
Lawania R.D., Mishra A., & Gupta R. 2010. Oroxylum indicum: A Review. Pharmacog J., 2(9): 304-310.
Mahomoodally, M.F., Gurib-Fakim, A, & Subratty A.H. 2005. Antimicrobial activities and phytochemical profiles of endemic medicinal plants of Mauritius. Pharmaceutical Biology., 43(3):237–242.
Manoharan, S., Murugaraj, M.P., Nagarethinam, P., Ramachandran, S., Sekar, K. & Shamsul, A.W. 2012. Chemopreventive Potential of Chrysin in 7,12- dimethylbenz(a)anthracene Induced Skin Carcinogenesis in Swiss Albino Mice. Int.J.Res.Pharm.Sci.,3(1), 86-96. India : Annamalai University.
Mantawy, E.M., El-Bakly, W.M., Esmat, A., Badr, A.M., & El-Demerdash, E. 2014. Chrysin alleviates acute doxorubicin cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis. Eur J Pharmacol, 728:107e18.
Maren, T.H. 1967. CA: chemistry, physiology, and inhibition. Physiol Rev 47:595- 781. Hodgen GD, Gomes WR & Vandemark NL (1971) A testicular isoenzyme of CA. Biol Reprod 4:224-228.
Maulina, D., Amin, M., Lestari, S.R., & Aziz, M. 2018. Chrysin as natural biopesticide from Mirabilis jalapa and its interaction with glutamate as an inhibitor in insects immune system. Journal of Biologival Researches, Vol. 23: 2. Doi: 10.23869/bphjbr.23.2.20185.
Mawson, C.A & Fischer, M.I. 1952. CA and zinc in prostate gland of the rat and rabbit. Arch Biochem Biophys., 36:485-486.
McIntosh, J. 1969. CA isoenzymes in the eryhrocytes and dorsolateral prostate of the rat. Biochem J, 14:463-467.
Mezquita, P., Mezquita, C & Mezquita, J. 1999. Novel transcripts of CA II in mouse and human testis. MHR: Basic science of reproductive medicine, 5 (3): 1 pp: 199–205.
Min Y, Sun T, Niu Z, & Liu F. 2016. Vitamin C and vitamin E supplementation alleviates oxidative stress induced by dexamethasone and improves fertility of breeder roosters. Anim Reprod Sci., 171:1e6.
Miyake, T & Pincus, G. 1959. Hormonal influences on the CA concentration in the accessory reproductive tracts of the rat. Endocrinology, 65:64-72.
Morissette, M., Litim, N., & Di Paolo T. 2017. Chapter 2 – Natural Phytoestrogens: A Class of Promising Neuroprotective Agents for Parkinson Disease. In Brahmachari G. Discovery and Development of Neuroprotective Agents from Natural Products. Elsevier Science. p. 32. doi:10.1016/B978-0-12-809593-5.00002-1. ISBN 978-0-12-809769-4.
Motaleb, M., Hossain, M., Alam, M., Abdullah-Al Mamun, M. & Sultana, M. 2013. Commonly Used Medicinal Herbs and Shrubs by Traditional Herbal Practitioners Glimpses from Thanchi upazila of Bandarban. IUCN, International Union for Conservation of Nature.
Neuman S, Lin T, & Heste P. 2002. The effect of dietary carnitine on semen traits of White Leghorn roosters. Poult Sci., 81:495e503.
Ommati, M.M., Zamiri, M.J., Akhlaghi, A, Atashi, H, Jafarzadeh, M.R., & Rezvani, M.R. 2013. Seminal characteristics, sperm fatty acids, and blood biochemical attributes in breeder roosters orally administered with sage (Salvia officinalis) extract. Anim Prod Sci., 53:548e54.
Pandey, A.K. 2010. Anti-staphylococcal activity of a pan-tropical aggressive and obnoxious weed Parihenium histerophorus: an in vitro study. National Academy Science Letters. 30(11-12):383–386.
Parkkila, S., Kaunisto, K, Kellokumpu, S & Rajaniemi, H. 1991. A high activity CA isoenzyme (CA II) is present in mammalian spermatozoa. Histochemistry, 95:477-482.
Pincus, G & Bialy, G. 1963. CA in steroid-responsive tissues. Recent Prog Horm Res, 19:201-250.
Rengaraj D, & Hong Y. Effects of dietary vitamin E on fertility functions in poultry species. Int J Mol Sci, 16:9910e21.
Ridderstråle Y, Ekstedt E & Plöen L. 1985. Localization of CA in testis. Acta Physiol Scand 124 Suppl 542:408.
Roy, M.K., Nakahara K., Na T.V., Trakoontivakorn G., Takenaka M., & Isobe S. 2007. Baicalein- a flavonoid extracted from a methanolic extract of Oroxylum indicum inhibits proliferation of a cancer cell line in vitro via induction of apoptosis. Pharmazie, 62(2): 149-153.
Salim, Z. & Munadi, E. 2017. Info Komoditi Tanaman Obat. Badan Pengkajian dan Pengembangan Perdagangan Kementerian Perdagangan Republik Indonesia
Sankara, S., &Nair, A.G.R. 1972. Flavonoids of stem bark of Oroxylum indicum. Curr Sci. 41: 62-63.
Tajima, Y, Okamura, N & Sugita, Y. 1987 The activating effects of bicarbonate on sperm motility and respiration at ejaculation. Biochem Biophys Acta, 924:519-529.
Tenpe C.R., Upaganlawar A., Burle S., &Yeole Y.G. 2009. In vitro antioxidant and preliminary hepatoprotective activity of Oroxylum indicum (Vent.) leaf extracts. Pharma online, 1: 35-43.
Tepsuwan A., Furihata C., Rojanapo W., & Matsuhima T. 1992. Genotoxicity and cell proliferative acitivity of a nitro-sated Oroxylum indicum (Vent.) fraction in the pyloric mucosa of rat stomach. Mutat Res., 281(1): 55-61.
Uddin, K.A., Sayeed, A., Rahman I.A.A., Khatun S., Khan G.R.M.A.M., & Sadik M.G. 2003. Biological activitives of extracts and two flavonoids from Oroxylum indicum Vent. (Bignoniaceae). J Biol Sci., 3(3): 371-375.
Upaganlawar B., & Tenpe C.R. 2007. In vitro antioxidant activity of leaves of Oroxylum indicum (Vent.). Biomed., 2(3): 300-304.
Waldeyer A & Häusler G. 1959. Histochemical studies of the CA activity of vas deferens and its accessory glands in the Mus Rattus. Acta Biol Germ Med., 2:568-589.
Walker, R. S., P. D. Burns, J. C. Whittier, G. E. Seidel, & D. D. Zalesky. 2005. Evaluation of gonadotropin releasing hormone and insemination time using the CO-synch protocol in beef cows. Prof. Anim. Sci., 21:190.
Yan R., Cao Y., Chen C., Dai H., Yu S., Wei J., Li H., & Yang B. 2011. Antioxidant flavonoids from the seed of Oroxylum indicum. Fitoterapia, 82: 841–884.
Zhandi, M., M Ansari, P Roknabadi, A Zare Shahneh & M Sharafi, 2017. Orally administered Chrysin improves post‐thawed sperm quality and fertility of rooster, Reproduction in Domestic Animals, 52, 6, (1004-1010).
DOI: https://doi.org/10.14421/biomedich.2020.91.27-32
Refbacks
- There are currently no refbacks.
Copyright (c) 2020 Mohamad Amin, Muhammad Najib Fahmi, Muhammad Andi Ali Ridho, Nurul Fitri, Umie Lestari, Dina Maulina, Ihya Fakhrurizal Amin
Biology, Medicine, & Natural Product Chemistry |
|
